Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats

Background. Natural products have been said to show immunomodulatory and antioxidant activities. The research study was aimed to assess the immunomodulatory and free radical scavenging activities of crude polysaccharide from dry mushroom fruiting bodies of Termitomyces le-testui. Materials and Metho...

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Main Authors: Foncham Evans Ngwenah, Kada Sanda Antoine, Salah Martin, Tume Christopher, Oumar Mahamat
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Advances in Pharmacological and Pharmaceutical Sciences
Online Access:http://dx.doi.org/10.1155/2021/5893210
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author Foncham Evans Ngwenah
Kada Sanda Antoine
Salah Martin
Tume Christopher
Oumar Mahamat
author_facet Foncham Evans Ngwenah
Kada Sanda Antoine
Salah Martin
Tume Christopher
Oumar Mahamat
author_sort Foncham Evans Ngwenah
collection DOAJ
description Background. Natural products have been said to show immunomodulatory and antioxidant activities. The research study was aimed to assess the immunomodulatory and free radical scavenging activities of crude polysaccharide from dry mushroom fruiting bodies of Termitomyces le-testui. Materials and Methods. Hot water extract of polysaccharide extract of T. le-testui was prepared and tested in white albino Wister rats for its immunomodulatory activities effect on methylprednisolone-immunosuppressed animals. In addition, the radical scavenging activity of the polysaccharide was evaluated using nitrite and hydrogen peroxide. Results. The result of the study showed that the polysaccharide T. le-testui increases the phagocytic index, energy metabolism of macrophages, spleen index, and nitric oxide in a concentration-dependent manner in immunosuppressed animals. Also, it was observed that the extract increased dose-dependent total oxidative stress and thymus index. Finally, the crude polysaccharide-rich extract showed nitrite and hydrogen peroxide scavenging activity in a concentration-dependent manner. Conclusion. Polysaccharide-rich extract possesses immunomodulatory and antioxidant properties.
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spelling doaj-art-8826bc6a2e1d468cb33ed44f5b9f067f2025-02-03T05:54:27ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902021-01-01202110.1155/2021/5893210Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in RatsFoncham Evans Ngwenah0Kada Sanda Antoine1Salah Martin2Tume Christopher3Oumar Mahamat4Laboratory of BiochemistryLaboratory of Biological SciencesLaboratory of Biological SciencesLaboratory of BiochemistryLaboratory of Biological SciencesBackground. Natural products have been said to show immunomodulatory and antioxidant activities. The research study was aimed to assess the immunomodulatory and free radical scavenging activities of crude polysaccharide from dry mushroom fruiting bodies of Termitomyces le-testui. Materials and Methods. Hot water extract of polysaccharide extract of T. le-testui was prepared and tested in white albino Wister rats for its immunomodulatory activities effect on methylprednisolone-immunosuppressed animals. In addition, the radical scavenging activity of the polysaccharide was evaluated using nitrite and hydrogen peroxide. Results. The result of the study showed that the polysaccharide T. le-testui increases the phagocytic index, energy metabolism of macrophages, spleen index, and nitric oxide in a concentration-dependent manner in immunosuppressed animals. Also, it was observed that the extract increased dose-dependent total oxidative stress and thymus index. Finally, the crude polysaccharide-rich extract showed nitrite and hydrogen peroxide scavenging activity in a concentration-dependent manner. Conclusion. Polysaccharide-rich extract possesses immunomodulatory and antioxidant properties.http://dx.doi.org/10.1155/2021/5893210
spellingShingle Foncham Evans Ngwenah
Kada Sanda Antoine
Salah Martin
Tume Christopher
Oumar Mahamat
Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
Advances in Pharmacological and Pharmaceutical Sciences
title Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_full Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_fullStr Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_full_unstemmed Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_short Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats
title_sort free radical scavenging capacities and alleviating actions of polysaccharides extract of termitomyces le testui on methylprednisolone induced immunodepression in rats
url http://dx.doi.org/10.1155/2021/5893210
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