Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice
It is unclear how docosahexaenoic acid (DHA) improves insulin resistance via modulating gut microbiome in obese individuals. We used diet-induced obesity (DIO) mice as a model to study the effects of DHA-rich fish oil (DHA-FO) on host metabolic disorders and colonic microbiome. DHA-FO reduced fat de...
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Tsinghua University Press
2022-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000847 |
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| author | Wanxiu Cao Fang Liu Robert W. Li Yaoxian Chin Yuming Wang Changhu Xue Qingjuan Tang |
| author_facet | Wanxiu Cao Fang Liu Robert W. Li Yaoxian Chin Yuming Wang Changhu Xue Qingjuan Tang |
| author_sort | Wanxiu Cao |
| collection | DOAJ |
| description | It is unclear how docosahexaenoic acid (DHA) improves insulin resistance via modulating gut microbiome in obese individuals. We used diet-induced obesity (DIO) mice as a model to study the effects of DHA-rich fish oil (DHA-FO) on host metabolic disorders and colonic microbiome. DHA-FO reduced fat deposition, regulated lipid profiles and alleviated insulin resistance in DIO mice. Probably because DHA-FO prevented the permeation of lipopolysaccharide across intestinal epithelial barrier, and promoted peptide YY (PYY) secretion via the mediation of short chain fatty acids receptor (FFAR2) in colon. Furthermore, DHA-FO might regulate PYY expression by reversing microbial dysbiosis, including increasing the abundance of Akkermansia muciniphila and Lactobacillus, and suppressing the growth of Helicobacter. DHA-FO also altered gut microbial function (e.g. “linoleic acid metabolism”) associated with PYY expression (r > 0.80, P < 0.05). Herein, DHA-FO enhanced insulin action on glucose metabolism by altering gut microbiome and facilitating colonic PYY expression in DIO mice. |
| format | Article |
| id | doaj-art-881cf8c6e305400eb987d048ae71b845 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-881cf8c6e305400eb987d048ae71b8452025-02-03T04:01:30ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-01111177188Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity miceWanxiu Cao0Fang Liu1Robert W. Li2Yaoxian Chin3Yuming Wang4Changhu Xue5Qingjuan Tang6College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaUnited States Department of Agriculture, Agriculture Research Service (USDA-ARS), Animal Genomics and Improvement Laboratory, Beltsville, MD 20705, USAHainan Tropical Ocean University, Sanya 572022, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Corresponding author at: College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.It is unclear how docosahexaenoic acid (DHA) improves insulin resistance via modulating gut microbiome in obese individuals. We used diet-induced obesity (DIO) mice as a model to study the effects of DHA-rich fish oil (DHA-FO) on host metabolic disorders and colonic microbiome. DHA-FO reduced fat deposition, regulated lipid profiles and alleviated insulin resistance in DIO mice. Probably because DHA-FO prevented the permeation of lipopolysaccharide across intestinal epithelial barrier, and promoted peptide YY (PYY) secretion via the mediation of short chain fatty acids receptor (FFAR2) in colon. Furthermore, DHA-FO might regulate PYY expression by reversing microbial dysbiosis, including increasing the abundance of Akkermansia muciniphila and Lactobacillus, and suppressing the growth of Helicobacter. DHA-FO also altered gut microbial function (e.g. “linoleic acid metabolism”) associated with PYY expression (r > 0.80, P < 0.05). Herein, DHA-FO enhanced insulin action on glucose metabolism by altering gut microbiome and facilitating colonic PYY expression in DIO mice.http://www.sciencedirect.com/science/article/pii/S2213453021000847Docosahexaenoic acidDiet-induced obesityInsulin resistancePeptide YYGut microbiome |
| spellingShingle | Wanxiu Cao Fang Liu Robert W. Li Yaoxian Chin Yuming Wang Changhu Xue Qingjuan Tang Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice Food Science and Human Wellness Docosahexaenoic acid Diet-induced obesity Insulin resistance Peptide YY Gut microbiome |
| title | Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice |
| title_full | Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice |
| title_fullStr | Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice |
| title_full_unstemmed | Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice |
| title_short | Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice |
| title_sort | docosahexaenoic acid rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide yy expression in diet induced obesity mice |
| topic | Docosahexaenoic acid Diet-induced obesity Insulin resistance Peptide YY Gut microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000847 |
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