A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease
BACKGROUND: Methotrexate (MTX) is effective in remission induction and maintenance in steroid-dependent Crohn's disease (CD), but is often considered to be a second-line immunosuppressive agent, to be used in cases of failure or intolerance to azathioprine (AZA) or 6-mercaptopurine (6-MP). This...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2005/382379 |
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| _version_ | 1832545797392039936 |
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| author | Nilesh Chande Terry Ponich James Gregor |
| author_facet | Nilesh Chande Terry Ponich James Gregor |
| author_sort | Nilesh Chande |
| collection | DOAJ |
| description | BACKGROUND: Methotrexate (MTX) is effective in remission induction and maintenance in steroid-dependent Crohn's disease (CD), but is often considered to be a second-line immunosuppressive agent, to be used in cases of failure or intolerance to azathioprine (AZA) or 6-mercaptopurine (6-MP). This may be related to concerns about hepatotoxicity, but this adverse effect is rare in monitored CD patients taking MTX. Still, there are no guidelines for monitoring patients with CD on MTX, and physicians must decide based on rheumatological literature about how to monitor their patients. |
| format | Article |
| id | doaj-art-87f8197fa47545c79a3d37afb29764c1 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-87f8197fa47545c79a3d37afb29764c12025-02-03T07:24:48ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-0119955355810.1155/2005/382379A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s DiseaseNilesh Chande0Terry Ponich1James Gregor2Division of Gastroenterology, University of Western Ontario, London Health Sciences Centre, London, Ontario, CanadaDivision of Gastroenterology, University of Western Ontario, London Health Sciences Centre, London, Ontario, CanadaDivision of Gastroenterology, University of Western Ontario, London Health Sciences Centre, London, Ontario, CanadaBACKGROUND: Methotrexate (MTX) is effective in remission induction and maintenance in steroid-dependent Crohn's disease (CD), but is often considered to be a second-line immunosuppressive agent, to be used in cases of failure or intolerance to azathioprine (AZA) or 6-mercaptopurine (6-MP). This may be related to concerns about hepatotoxicity, but this adverse effect is rare in monitored CD patients taking MTX. Still, there are no guidelines for monitoring patients with CD on MTX, and physicians must decide based on rheumatological literature about how to monitor their patients.http://dx.doi.org/10.1155/2005/382379 |
| spellingShingle | Nilesh Chande Terry Ponich James Gregor A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease Canadian Journal of Gastroenterology |
| title | A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease |
| title_full | A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease |
| title_fullStr | A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease |
| title_full_unstemmed | A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease |
| title_short | A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease |
| title_sort | survey of canadian gastroenterologists about the use of methotrexate in patients with crohn s disease |
| url | http://dx.doi.org/10.1155/2005/382379 |
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