Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana
Objective. Peripheral arterial disease (PAD) is a common complication of diabetes, associated with impairment in angiogenesis. Angiogenesis is regulated by angiogenic growth factors such as angiopoietin 1 (Ang-1), Ang-2, and vascular endothelial growth factor (VEGF). We studied the association betwe...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/2390174 |
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| author | Kwame Yeboah Jennifer A. Agyekum Eric Kyei Baafour Daniel A. Antwi Afua B. Adjei Vincent Boima Ben Gyan |
| author_facet | Kwame Yeboah Jennifer A. Agyekum Eric Kyei Baafour Daniel A. Antwi Afua B. Adjei Vincent Boima Ben Gyan |
| author_sort | Kwame Yeboah |
| collection | DOAJ |
| description | Objective. Peripheral arterial disease (PAD) is a common complication of diabetes, associated with impairment in angiogenesis. Angiogenesis is regulated by angiogenic growth factors such as angiopoietin 1 (Ang-1), Ang-2, and vascular endothelial growth factor (VEGF). We studied the association between angiogenic growth factors versus PAD and exertional leg symptoms in diabetes patients in Ghana. Method. In this cross-sectional study, ankle-brachial index was measured with oscillometrically and exertional leg symptoms were screened with Edinburgh claudication questionnaire in 140 diabetes patients and 110 nondiabetes individuals. Circulating levels of Ang-1, Ang-2, and VEGF were measured with immunosorbent assay. Results. The prevalence of PAD and exertional leg pain was 16.8% and 24.8%, respectively. Compared to non-PAD participants, PAD patients had higher VEGF levels [85.8 (37.5–154.5) versus 57.7 (16.6–161.1) p=0.032] and lower Ang-1 levels [31.3 (24.8–42.6) versus 40.9 (28.2–62.1), p=0.017]. In multivariable logistic regression, patients with exertional leg pain had increased the odds of plasma Ang-2 levels [OR (95% CI): 2.08 (1.08–6.41), p=0.036]. Conclusion. Diabetes patients with PAD and exertional leg pain have imbalance in angiogenic growth factors, indicating impaired angiogenesis. In patients with exertional leg pains, Ang-2 may be an important biomarker. |
| format | Article |
| id | doaj-art-87f2958d353b4d8fa917f9e73c222b26 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-87f2958d353b4d8fa917f9e73c222b262025-02-03T05:48:00ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322017-01-01201710.1155/2017/23901742390174Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in GhanaKwame Yeboah0Jennifer A. Agyekum1Eric Kyei Baafour2Daniel A. Antwi3Afua B. Adjei4Vincent Boima5Ben Gyan6Department of Physiology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, GhanaDepartment of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, GhanaDepartment of Physiology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, GhanaDepartment of Chemical Pathology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, GhanaDepartment of Medicine & Therapeutics, School of Medicine & Dentistry, University of Ghana, Accra, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, GhanaObjective. Peripheral arterial disease (PAD) is a common complication of diabetes, associated with impairment in angiogenesis. Angiogenesis is regulated by angiogenic growth factors such as angiopoietin 1 (Ang-1), Ang-2, and vascular endothelial growth factor (VEGF). We studied the association between angiogenic growth factors versus PAD and exertional leg symptoms in diabetes patients in Ghana. Method. In this cross-sectional study, ankle-brachial index was measured with oscillometrically and exertional leg symptoms were screened with Edinburgh claudication questionnaire in 140 diabetes patients and 110 nondiabetes individuals. Circulating levels of Ang-1, Ang-2, and VEGF were measured with immunosorbent assay. Results. The prevalence of PAD and exertional leg pain was 16.8% and 24.8%, respectively. Compared to non-PAD participants, PAD patients had higher VEGF levels [85.8 (37.5–154.5) versus 57.7 (16.6–161.1) p=0.032] and lower Ang-1 levels [31.3 (24.8–42.6) versus 40.9 (28.2–62.1), p=0.017]. In multivariable logistic regression, patients with exertional leg pain had increased the odds of plasma Ang-2 levels [OR (95% CI): 2.08 (1.08–6.41), p=0.036]. Conclusion. Diabetes patients with PAD and exertional leg pain have imbalance in angiogenic growth factors, indicating impaired angiogenesis. In patients with exertional leg pains, Ang-2 may be an important biomarker.http://dx.doi.org/10.1155/2017/2390174 |
| spellingShingle | Kwame Yeboah Jennifer A. Agyekum Eric Kyei Baafour Daniel A. Antwi Afua B. Adjei Vincent Boima Ben Gyan Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana International Journal of Vascular Medicine |
| title | Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana |
| title_full | Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana |
| title_fullStr | Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana |
| title_full_unstemmed | Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana |
| title_short | Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana |
| title_sort | circulating angiogenic growth factors in diabetes patients with peripheral arterial disease and exertional leg pain in ghana |
| url | http://dx.doi.org/10.1155/2017/2390174 |
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