The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
The protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic st...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/1721069 |
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| author | Piotr Seliger Danuta Tomczyk Grzegorz Andrijewski Ewa Tomal |
| author_facet | Piotr Seliger Danuta Tomczyk Grzegorz Andrijewski Ewa Tomal |
| author_sort | Piotr Seliger |
| collection | DOAJ |
| description | The protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic strength. The influence of cavity size, location of protonation sites, and attached substituents of the macrocyclic ligands on the protonation constants were discussed on the basis of potentiometric measurement as well as H1-NMR results. |
| format | Article |
| id | doaj-art-87d55b93273c47dc8af06c84e5af1935 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-87d55b93273c47dc8af06c84e5af19352025-02-03T01:31:40ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732016-01-01201610.1155/2016/17210691721069The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water MixturesPiotr Seliger0Danuta Tomczyk1Grzegorz Andrijewski2Ewa Tomal3Department of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, PolandDepartment of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, PolandDepartment of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, PolandDepartment of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University in Kielce, Swietokrzyska 15 A, 25-406 Kielce, PolandThe protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic strength. The influence of cavity size, location of protonation sites, and attached substituents of the macrocyclic ligands on the protonation constants were discussed on the basis of potentiometric measurement as well as H1-NMR results.http://dx.doi.org/10.1155/2016/1721069 |
| spellingShingle | Piotr Seliger Danuta Tomczyk Grzegorz Andrijewski Ewa Tomal The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures Journal of Analytical Methods in Chemistry |
| title | The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures |
| title_full | The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures |
| title_fullStr | The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures |
| title_full_unstemmed | The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures |
| title_short | The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures |
| title_sort | determination of protonation constants of peptidomimetic cyclophanes in binary methanol water mixtures |
| url | http://dx.doi.org/10.1155/2016/1721069 |
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