Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death
On December 16, 2015, the Food and Drug Administration (FDA) in the United States approved sugammadex (Bridion, Merck and Co), a modified gamma-cyclodextrin, to be used as a reversal agent. It is a first and unique selective nondepolarizing steroidal muscle relaxant (NDSMR) binding agent with a grea...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Anesthesiology |
| Online Access: | http://dx.doi.org/10.1155/2020/8767195 |
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| _version_ | 1832547159557275648 |
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| author | Kazim Mirza Kathryn Landoski Dilip Thakar Jagtar Heir-Singh Timothy Jackson Cynthia Kassab |
| author_facet | Kazim Mirza Kathryn Landoski Dilip Thakar Jagtar Heir-Singh Timothy Jackson Cynthia Kassab |
| author_sort | Kazim Mirza |
| collection | DOAJ |
| description | On December 16, 2015, the Food and Drug Administration (FDA) in the United States approved sugammadex (Bridion, Merck and Co), a modified gamma-cyclodextrin, to be used as a reversal agent. It is a first and unique selective nondepolarizing steroidal muscle relaxant (NDSMR) binding agent with a great affinity for rocuronium and vecuronium. However, there have been several recently published case reports of bradycardia and asystole immediately after sugammadex administration for the reversal. This report presents a case of sugammadex administration followed by rapidly progressing bradycardia leading to asystole and subsequent death. The family has provided the written consent to share this case report. |
| format | Article |
| id | doaj-art-87c01c19340446d79ad1910fe8d61903 |
| institution | Kabale University |
| issn | 2090-6382 2090-6390 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Anesthesiology |
| spelling | doaj-art-87c01c19340446d79ad1910fe8d619032025-02-03T06:45:49ZengWileyCase Reports in Anesthesiology2090-63822090-63902020-01-01202010.1155/2020/87671958767195Sugammadex-Associated Hypotension, Bradycardia, Asystole, and DeathKazim Mirza0Kathryn Landoski1Dilip Thakar2Jagtar Heir-Singh3Timothy Jackson4Cynthia Kassab5MD Anderson Cancer Center, Houston, TX, USAMD Anderson Cancer Center, Houston, TX, USAMD Anderson Cancer Center, Houston, TX, USAMD Anderson Cancer Center, Houston, TX, USAMD Anderson Cancer Center, Houston, TX, USAMD Anderson Cancer Center, Houston, TX, USAOn December 16, 2015, the Food and Drug Administration (FDA) in the United States approved sugammadex (Bridion, Merck and Co), a modified gamma-cyclodextrin, to be used as a reversal agent. It is a first and unique selective nondepolarizing steroidal muscle relaxant (NDSMR) binding agent with a great affinity for rocuronium and vecuronium. However, there have been several recently published case reports of bradycardia and asystole immediately after sugammadex administration for the reversal. This report presents a case of sugammadex administration followed by rapidly progressing bradycardia leading to asystole and subsequent death. The family has provided the written consent to share this case report.http://dx.doi.org/10.1155/2020/8767195 |
| spellingShingle | Kazim Mirza Kathryn Landoski Dilip Thakar Jagtar Heir-Singh Timothy Jackson Cynthia Kassab Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death Case Reports in Anesthesiology |
| title | Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death |
| title_full | Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death |
| title_fullStr | Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death |
| title_full_unstemmed | Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death |
| title_short | Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death |
| title_sort | sugammadex associated hypotension bradycardia asystole and death |
| url | http://dx.doi.org/10.1155/2020/8767195 |
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