Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs
Abstract Background The advantages of insulin degludec 100 U/mL (IDeg100) in the treatment of diabetes mellitus (DM) include consistent release, predictable glucose‐lowering effect, and minimal day‐to‐day variability. Hypothesis/Objectives To describe the use of IDeg100 in dogs with DM, level of dia...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17303 |
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| author | Jocelyn Mott Arnon Gal Antonio Maria Tardo Alisa Berg Riley Claude Alexis Hoelmer Mei Lun Mui Avin Arjoonsingh Chen Gilor |
| author_facet | Jocelyn Mott Arnon Gal Antonio Maria Tardo Alisa Berg Riley Claude Alexis Hoelmer Mei Lun Mui Avin Arjoonsingh Chen Gilor |
| author_sort | Jocelyn Mott |
| collection | DOAJ |
| description | Abstract Background The advantages of insulin degludec 100 U/mL (IDeg100) in the treatment of diabetes mellitus (DM) include consistent release, predictable glucose‐lowering effect, and minimal day‐to‐day variability. Hypothesis/Objectives To describe the use of IDeg100 in dogs with DM, level of diabetic control and adverse effects. Animals Thirty‐three client‐owned dogs with DM. Methods A prospective, multi‐institutional, uncontrolled study of newly diagnosed or previously insulin‐treated, with or without comorbidities and with or without concurrent medications. Clinical signs and continuous glucose monitoring data were monitored and guided insulin dose adjustments. A per‐protocol analysis was performed. Results The final dose of IDeg100 in dogs was 1.3 U/kg (median, range, 0.4‐2.2) achieved in 14 days (median, range, 3‐32). Seventy‐nine percent (26/33) of the dogs had comorbidities with 42% (11/26) having more than 1 comorbidity. Sixty‐four percent (21/33) of dogs were receiving concurrent medications with 62% (13/21) receiving more than 1 non‐insulin medication. Seventy‐six percent (25/33) were scored as having excellent/very good DM control. From baseline to study exit, dogs showed improvements in both ALIVE DM clinical score (from 3 [0‐8, 96.49% CI (2‐5)] to 1 [0‐7, 96.49% CI (1‐2)]; P = .0007) and average 3‐day interstitial glucose (from 332.8 ± 68.7 mg/dL, 95% CI [308.8‐357.2] to 229.0 ± 56.3 mg/dL [CI 209.0 ‐ 248.9]; P < .0001). Conclusions and Clinical Importance Insulin degludec 100 U/mL is effective for the treatment of dogs with DM. Eighty‐four percent (28/33) of dogs responded to once daily dose of IDeg100 with low frequency of clinical hypoglycemia. |
| format | Article |
| id | doaj-art-87bb6c82e859450cb83bd7cef06593d6 |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-87bb6c82e859450cb83bd7cef06593d62025-01-27T15:22:41ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-01-01391n/an/a10.1111/jvim.17303Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogsJocelyn Mott0Arnon Gal1Antonio Maria Tardo2Alisa Berg3Riley Claude4Alexis Hoelmer5Mei Lun Mui6Avin Arjoonsingh7Chen Gilor8Department of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USADepartment of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois at Urbana‐Champaign Urbana Illinois USADepartment of Veterinary Medical Sciences University of Bologna Ozzano dell'Emilia ItalyDepartment of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USADepartment of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USADepartment of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USADepartment of Clinical Sciences Colorado State University Fort Collins Colorado USADepartment of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USADepartment of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USAAbstract Background The advantages of insulin degludec 100 U/mL (IDeg100) in the treatment of diabetes mellitus (DM) include consistent release, predictable glucose‐lowering effect, and minimal day‐to‐day variability. Hypothesis/Objectives To describe the use of IDeg100 in dogs with DM, level of diabetic control and adverse effects. Animals Thirty‐three client‐owned dogs with DM. Methods A prospective, multi‐institutional, uncontrolled study of newly diagnosed or previously insulin‐treated, with or without comorbidities and with or without concurrent medications. Clinical signs and continuous glucose monitoring data were monitored and guided insulin dose adjustments. A per‐protocol analysis was performed. Results The final dose of IDeg100 in dogs was 1.3 U/kg (median, range, 0.4‐2.2) achieved in 14 days (median, range, 3‐32). Seventy‐nine percent (26/33) of the dogs had comorbidities with 42% (11/26) having more than 1 comorbidity. Sixty‐four percent (21/33) of dogs were receiving concurrent medications with 62% (13/21) receiving more than 1 non‐insulin medication. Seventy‐six percent (25/33) were scored as having excellent/very good DM control. From baseline to study exit, dogs showed improvements in both ALIVE DM clinical score (from 3 [0‐8, 96.49% CI (2‐5)] to 1 [0‐7, 96.49% CI (1‐2)]; P = .0007) and average 3‐day interstitial glucose (from 332.8 ± 68.7 mg/dL, 95% CI [308.8‐357.2] to 229.0 ± 56.3 mg/dL [CI 209.0 ‐ 248.9]; P < .0001). Conclusions and Clinical Importance Insulin degludec 100 U/mL is effective for the treatment of dogs with DM. Eighty‐four percent (28/33) of dogs responded to once daily dose of IDeg100 with low frequency of clinical hypoglycemia.https://doi.org/10.1111/jvim.17303basal insulincaninecontinuous glucose monitoringdiabetes mellitusonce‐daily insulintresiba |
| spellingShingle | Jocelyn Mott Arnon Gal Antonio Maria Tardo Alisa Berg Riley Claude Alexis Hoelmer Mei Lun Mui Avin Arjoonsingh Chen Gilor Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs Journal of Veterinary Internal Medicine basal insulin canine continuous glucose monitoring diabetes mellitus once‐daily insulin tresiba |
| title | Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs |
| title_full | Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs |
| title_fullStr | Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs |
| title_full_unstemmed | Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs |
| title_short | Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs |
| title_sort | insulin degludec 100 u ml for treatment of spontaneous diabetes mellitus in dogs |
| topic | basal insulin canine continuous glucose monitoring diabetes mellitus once‐daily insulin tresiba |
| url | https://doi.org/10.1111/jvim.17303 |
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