Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy
Human cases of avian influenza A(H5N2) and A(H5N1) viruses associated with outbreaks in birds and mammals are increasing globally, raising concerns about the possibility of a future avian influenza pandemic. We conducted a systematic review examining 30 reported cases of avian influenza in pregnant...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-01-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/1/24-1343_article |
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| author | Rachael Purcell Michelle L. Giles Nigel W. Crawford Jim Buttery |
| author_facet | Rachael Purcell Michelle L. Giles Nigel W. Crawford Jim Buttery |
| author_sort | Rachael Purcell |
| collection | DOAJ |
| description |
Human cases of avian influenza A(H5N2) and A(H5N1) viruses associated with outbreaks in birds and mammals are increasing globally, raising concerns about the possibility of a future avian influenza pandemic. We conducted a systematic review examining 30 reported cases of avian influenza in pregnant women. We found high mortality rates for mothers (90.0%, 27/30) and their babies (86.7%, 26/30) when women were infected with avian influenza virus during pregnancy. Despite being a high-risk population and having worse health outcomes across multiple pandemics, pregnant women are often excluded from vaccine trials. However, as the risk for a new pandemic increases and human vaccines against avian influenza are developed, early inclusion of pregnant women in clinical trials can inform the risk–benefit analysis for both the mother and their newborn infant. Early inclusion of pregnant women in public health vaccination programs is vital for protecting this high-risk population.
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| format | Article |
| id | doaj-art-87b5a3b35d624fe482cede9abee73894 |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-87b5a3b35d624fe482cede9abee738942025-08-20T02:39:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-01-01311505610.3201/eid3101.241343Systematic Review of Avian Influenza Virus Infection and Outcomes during PregnancyRachael PurcellMichelle L. GilesNigel W. CrawfordJim Buttery Human cases of avian influenza A(H5N2) and A(H5N1) viruses associated with outbreaks in birds and mammals are increasing globally, raising concerns about the possibility of a future avian influenza pandemic. We conducted a systematic review examining 30 reported cases of avian influenza in pregnant women. We found high mortality rates for mothers (90.0%, 27/30) and their babies (86.7%, 26/30) when women were infected with avian influenza virus during pregnancy. Despite being a high-risk population and having worse health outcomes across multiple pandemics, pregnant women are often excluded from vaccine trials. However, as the risk for a new pandemic increases and human vaccines against avian influenza are developed, early inclusion of pregnant women in clinical trials can inform the risk–benefit analysis for both the mother and their newborn infant. Early inclusion of pregnant women in public health vaccination programs is vital for protecting this high-risk population. https://wwwnc.cdc.gov/eid/article/31/1/24-1343_articleavian influenza virusinfluenzaviruseszoonosesrespiratory infectionspregnancy |
| spellingShingle | Rachael Purcell Michelle L. Giles Nigel W. Crawford Jim Buttery Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy Emerging Infectious Diseases avian influenza virus influenza viruses zoonoses respiratory infections pregnancy |
| title | Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy |
| title_full | Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy |
| title_fullStr | Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy |
| title_full_unstemmed | Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy |
| title_short | Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy |
| title_sort | systematic review of avian influenza virus infection and outcomes during pregnancy |
| topic | avian influenza virus influenza viruses zoonoses respiratory infections pregnancy |
| url | https://wwwnc.cdc.gov/eid/article/31/1/24-1343_article |
| work_keys_str_mv | AT rachaelpurcell systematicreviewofavianinfluenzavirusinfectionandoutcomesduringpregnancy AT michellelgiles systematicreviewofavianinfluenzavirusinfectionandoutcomesduringpregnancy AT nigelwcrawford systematicreviewofavianinfluenzavirusinfectionandoutcomesduringpregnancy AT jimbuttery systematicreviewofavianinfluenzavirusinfectionandoutcomesduringpregnancy |