Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?

Clozapine is an atypical antipsychotic used for treatment resistant schizophrenia. Its potential to induce agranulocytosis is well known but it can also cause myocarditis. Clozapine is the only antipsychotic known to induce this side effect, typically early in the treatment, and literature is scarc...

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Main Authors: T. A. Munshi, D. Volochniouk, T. Hassan, N. Mazhar
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Case Reports in Psychiatry
Online Access:http://dx.doi.org/10.1155/2014/513108
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author T. A. Munshi
D. Volochniouk
T. Hassan
N. Mazhar
author_facet T. A. Munshi
D. Volochniouk
T. Hassan
N. Mazhar
author_sort T. A. Munshi
collection DOAJ
description Clozapine is an atypical antipsychotic used for treatment resistant schizophrenia. Its potential to induce agranulocytosis is well known but it can also cause myocarditis. Clozapine is the only antipsychotic known to induce this side effect, typically early in the treatment, and literature is scarce on this condition. We are presenting a case report of a 21-year-old schizophrenic male who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. We then aim to review some of the available literature and raise awareness among physicians as this condition can potentially be fatal if not detected early.
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institution Kabale University
issn 2090-682X
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language English
publishDate 2014-01-01
publisher Wiley
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series Case Reports in Psychiatry
spelling doaj-art-87b4b3b6475b43f9bbfbc716f1bddab32025-02-03T01:13:14ZengWileyCase Reports in Psychiatry2090-682X2090-68382014-01-01201410.1155/2014/513108513108Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?T. A. Munshi0D. Volochniouk1T. Hassan2N. Mazhar3Queen’s University, 385 Princess Street, Kingston, ON, K7L 1B9, CanadaQueen’s University, 385 Princess Street, Kingston, ON, K7L 1B9, CanadaQueen’s University, 385 Princess Street, Kingston, ON, K7L 1B9, CanadaQueen’s University, 385 Princess Street, Kingston, ON, K7L 1B9, CanadaClozapine is an atypical antipsychotic used for treatment resistant schizophrenia. Its potential to induce agranulocytosis is well known but it can also cause myocarditis. Clozapine is the only antipsychotic known to induce this side effect, typically early in the treatment, and literature is scarce on this condition. We are presenting a case report of a 21-year-old schizophrenic male who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. We then aim to review some of the available literature and raise awareness among physicians as this condition can potentially be fatal if not detected early.http://dx.doi.org/10.1155/2014/513108
spellingShingle T. A. Munshi
D. Volochniouk
T. Hassan
N. Mazhar
Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?
Case Reports in Psychiatry
title Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?
title_full Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?
title_fullStr Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?
title_full_unstemmed Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?
title_short Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?
title_sort clozapine induced myocarditis is mandatory monitoring warranted for its early recognition
url http://dx.doi.org/10.1155/2014/513108
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AT dvolochniouk clozapineinducedmyocarditisismandatorymonitoringwarrantedforitsearlyrecognition
AT thassan clozapineinducedmyocarditisismandatorymonitoringwarrantedforitsearlyrecognition
AT nmazhar clozapineinducedmyocarditisismandatorymonitoringwarrantedforitsearlyrecognition