Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected mice
Malaria disease is caused by a variant of mosquitoes that leads to transmission in humans. This study aimed to investigate the effects of beetroot extract (NBE) nanoparticles on parasitemia index and ICAM-1 levels in mice infected with Plasmodium berghei. Thirty male mice were randomly divided into...
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Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology
2025-03-01
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| Series: | Journal of Advanced Biotechnology and Experimental Therapeutics |
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| Online Access: | https://www.bsmiab.org/jabet/?mno=209890 |
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| author | Fransisca Pramesshinta Hardimarta Lisyani Budipradigda Suromo Kis Djamiatun |
| author_facet | Fransisca Pramesshinta Hardimarta Lisyani Budipradigda Suromo Kis Djamiatun |
| author_sort | Fransisca Pramesshinta Hardimarta |
| collection | DOAJ |
| description | Malaria disease is caused by a variant of mosquitoes that leads to transmission in humans. This study aimed to investigate the effects of beetroot extract (NBE) nanoparticles on parasitemia index and ICAM-1 levels in mice infected with Plasmodium berghei. Thirty male mice were randomly divided into six groups including H= baseline (normal/healthy), NC= P. berghei inoculation, PC= P. berghei inoculation treated with artemisinin, T1= P. berghei inoculation treated with artemisinin and NBE (50 mg/kg), T2= P. berghei inoculation treated with artemisinin and NBE (100 mg/kg), and T3= P. berghei inoculation treated with artemisinin and NBE (200 mg/kg). Parasitemia index in groups T2 (13.1%) and T3 (12.5 %) were significantly lower compared to groups NC (36 %) and PC (16.2 %). Furthermore, ICAM-1 levels in groups T2 (145.72 ng/ml) and T3 (151.24 ng/ml) were significantly lower compared to groups NC (319.17 ng/ml) and PC (241.93 ng/ml). The findings of the study suggest that nanoparticles of beetroot extract could have potential as an anti-inflammatory and antimalarial adjuvant for malaria infection. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 55-63] |
| format | Article |
| id | doaj-art-879a65468dcb4a3d99049c4768ae1370 |
| institution | Kabale University |
| issn | 2616-4760 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology |
| record_format | Article |
| series | Journal of Advanced Biotechnology and Experimental Therapeutics |
| spelling | doaj-art-879a65468dcb4a3d99049c4768ae13702025-01-30T13:01:08ZengBangladesh Society for Microbiology, Immunology, and Advanced BiotechnologyJournal of Advanced Biotechnology and Experimental Therapeutics2616-47602025-03-0181556310.5455/jabet.2025.05209890Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected miceFransisca Pramesshinta Hardimarta0Lisyani Budipradigda Suromo1Kis Djamiatun2Doctoral Study Program of Medical and Health Science, Diponegoro University Departement of Clinical Pathology, Faculty of Medicine, Diponegoro University Faculty of Medicine, Diponegoro UniversityMalaria disease is caused by a variant of mosquitoes that leads to transmission in humans. This study aimed to investigate the effects of beetroot extract (NBE) nanoparticles on parasitemia index and ICAM-1 levels in mice infected with Plasmodium berghei. Thirty male mice were randomly divided into six groups including H= baseline (normal/healthy), NC= P. berghei inoculation, PC= P. berghei inoculation treated with artemisinin, T1= P. berghei inoculation treated with artemisinin and NBE (50 mg/kg), T2= P. berghei inoculation treated with artemisinin and NBE (100 mg/kg), and T3= P. berghei inoculation treated with artemisinin and NBE (200 mg/kg). Parasitemia index in groups T2 (13.1%) and T3 (12.5 %) were significantly lower compared to groups NC (36 %) and PC (16.2 %). Furthermore, ICAM-1 levels in groups T2 (145.72 ng/ml) and T3 (151.24 ng/ml) were significantly lower compared to groups NC (319.17 ng/ml) and PC (241.93 ng/ml). The findings of the study suggest that nanoparticles of beetroot extract could have potential as an anti-inflammatory and antimalarial adjuvant for malaria infection. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 55-63]https://www.bsmiab.org/jabet/?mno=209890beetrooticam-1parasitemia indexplasmodium bergheimalariananoparticle |
| spellingShingle | Fransisca Pramesshinta Hardimarta Lisyani Budipradigda Suromo Kis Djamiatun Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected mice Journal of Advanced Biotechnology and Experimental Therapeutics beetroot icam-1 parasitemia index plasmodium berghei malaria nanoparticle |
| title | Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected mice |
| title_full | Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected mice |
| title_fullStr | Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected mice |
| title_full_unstemmed | Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected mice |
| title_short | Nanoparticles of beetroot extract: A potential antimalarial adjuvant in Plasmodium berghei-infected mice |
| title_sort | nanoparticles of beetroot extract a potential antimalarial adjuvant in plasmodium berghei infected mice |
| topic | beetroot icam-1 parasitemia index plasmodium berghei malaria nanoparticle |
| url | https://www.bsmiab.org/jabet/?mno=209890 |
| work_keys_str_mv | AT fransiscapramesshintahardimarta nanoparticlesofbeetrootextractapotentialantimalarialadjuvantinplasmodiumbergheiinfectedmice AT lisyanibudipradigdasuromo nanoparticlesofbeetrootextractapotentialantimalarialadjuvantinplasmodiumbergheiinfectedmice AT kisdjamiatun nanoparticlesofbeetrootextractapotentialantimalarialadjuvantinplasmodiumbergheiinfectedmice |