Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets
Two simple, rapid, sensitive, precise and economic spectrophotometric methods have been developed for the estimation of etoricoxib in tablet formulation. During the course of study, it was observed that acidic solution of the drug formed colored ion-association complexes with Bromocresol Green (BCG)...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/280961 |
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| _version_ | 1832558944626671616 |
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| author | Kamal Shah Alka Gupta Pradeep Mishra |
| author_facet | Kamal Shah Alka Gupta Pradeep Mishra |
| author_sort | Kamal Shah |
| collection | DOAJ |
| description | Two simple, rapid, sensitive, precise and economic spectrophotometric methods have been developed for the estimation of etoricoxib in tablet formulation. During the course of study, it was observed that acidic solution of the drug formed colored ion-association complexes with Bromocresol Green (BCG) and Bromocresol Purple (BCP) which were soluble in chloroform. This property of the drug was followed for the development of colorimetric methods for analysis of drug. The complex of etoricoxib with BCG and BCP showed λmax at 416 nm and 408 nm respectively. These methods were validated statistically. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The proposed methods are found to be simple, accurate and reproducible that was successfully applied for the analysis of tablet formulation. |
| format | Article |
| id | doaj-art-8790a82b424049bfa0d13e5fc0c51a52 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-8790a82b424049bfa0d13e5fc0c51a522025-02-03T01:31:11ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016120721210.1155/2009/280961Extractive Spectrophotometric Methods for the Determination of Etoricoxib in TabletsKamal Shah0Alka Gupta1Pradeep Mishra2GLA, Institute of Pharmaceutical Research, Mathura (U.P.), IndiaIPS College of Pharmacy, Gwalior, (M.P.), IndiaDr. Hari Singh Gour University, Sagar, (M.P.), IndiaTwo simple, rapid, sensitive, precise and economic spectrophotometric methods have been developed for the estimation of etoricoxib in tablet formulation. During the course of study, it was observed that acidic solution of the drug formed colored ion-association complexes with Bromocresol Green (BCG) and Bromocresol Purple (BCP) which were soluble in chloroform. This property of the drug was followed for the development of colorimetric methods for analysis of drug. The complex of etoricoxib with BCG and BCP showed λmax at 416 nm and 408 nm respectively. These methods were validated statistically. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The proposed methods are found to be simple, accurate and reproducible that was successfully applied for the analysis of tablet formulation.http://dx.doi.org/10.1155/2009/280961 |
| spellingShingle | Kamal Shah Alka Gupta Pradeep Mishra Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets E-Journal of Chemistry |
| title | Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets |
| title_full | Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets |
| title_fullStr | Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets |
| title_full_unstemmed | Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets |
| title_short | Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets |
| title_sort | extractive spectrophotometric methods for the determination of etoricoxib in tablets |
| url | http://dx.doi.org/10.1155/2009/280961 |
| work_keys_str_mv | AT kamalshah extractivespectrophotometricmethodsforthedeterminationofetoricoxibintablets AT alkagupta extractivespectrophotometricmethodsforthedeterminationofetoricoxibintablets AT pradeepmishra extractivespectrophotometricmethodsforthedeterminationofetoricoxibintablets |