Role of New Biomarkers: Functional and Structural Damage
Traditional diagnosis of acute kidney injury (AKI) depends on detection of oliguria and rise of serum creatinine level, which is an unreliable and delayed marker of kidney damage. Delayed diagnosis of AKI in the critically ill patient is related to increased morbidity and mortality, prolonged length...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/361078 |
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| author | Evdoxia Tsigou Vasiliki Psallida Christos Demponeras Eleni Boutzouka George Baltopoulos |
| author_facet | Evdoxia Tsigou Vasiliki Psallida Christos Demponeras Eleni Boutzouka George Baltopoulos |
| author_sort | Evdoxia Tsigou |
| collection | DOAJ |
| description | Traditional diagnosis of acute kidney injury (AKI) depends on detection of oliguria and rise of serum creatinine level, which is an unreliable and delayed marker of kidney damage. Delayed diagnosis of AKI in the critically ill patient is related to increased morbidity and mortality, prolonged length of stay, and cost escalation. The discovery of a reliable biomarker for early diagnosis of AKI would be very helpful in facilitating early intervention, evaluating the effectiveness of therapy, and eventually reducing cost and improving outcome. Innovative technologies such as genomics and proteomics have contributed to the discovery of new biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys C), kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP). The current status of the most promising of these novel AKI biomarkers, including NGAL, Cys C, KIM-1, L-FABP, and IL-18, is reviewed. |
| format | Article |
| id | doaj-art-87893292efdf45d3b5b96065f1e09dad |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-87893292efdf45d3b5b96065f1e09dad2025-02-03T00:59:32ZengWileyCritical Care Research and Practice2090-13052090-13132013-01-01201310.1155/2013/361078361078Role of New Biomarkers: Functional and Structural DamageEvdoxia Tsigou0Vasiliki Psallida1Christos Demponeras2Eleni Boutzouka3George Baltopoulos4Athens University School of Nursing ICU, “Agioi Anargyroi” General Hospital, Kifisia, 14564 Athens, GreeceAthens University School of Nursing ICU, “Agioi Anargyroi” General Hospital, Kifisia, 14564 Athens, GreeceAthens University School of Nursing ICU, “Agioi Anargyroi” General Hospital, Kifisia, 14564 Athens, GreeceAthens University School of Nursing ICU, “Agioi Anargyroi” General Hospital, Kifisia, 14564 Athens, GreeceAthens University School of Nursing ICU, “Agioi Anargyroi” General Hospital, Kifisia, 14564 Athens, GreeceTraditional diagnosis of acute kidney injury (AKI) depends on detection of oliguria and rise of serum creatinine level, which is an unreliable and delayed marker of kidney damage. Delayed diagnosis of AKI in the critically ill patient is related to increased morbidity and mortality, prolonged length of stay, and cost escalation. The discovery of a reliable biomarker for early diagnosis of AKI would be very helpful in facilitating early intervention, evaluating the effectiveness of therapy, and eventually reducing cost and improving outcome. Innovative technologies such as genomics and proteomics have contributed to the discovery of new biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys C), kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP). The current status of the most promising of these novel AKI biomarkers, including NGAL, Cys C, KIM-1, L-FABP, and IL-18, is reviewed.http://dx.doi.org/10.1155/2013/361078 |
| spellingShingle | Evdoxia Tsigou Vasiliki Psallida Christos Demponeras Eleni Boutzouka George Baltopoulos Role of New Biomarkers: Functional and Structural Damage Critical Care Research and Practice |
| title | Role of New Biomarkers: Functional and Structural Damage |
| title_full | Role of New Biomarkers: Functional and Structural Damage |
| title_fullStr | Role of New Biomarkers: Functional and Structural Damage |
| title_full_unstemmed | Role of New Biomarkers: Functional and Structural Damage |
| title_short | Role of New Biomarkers: Functional and Structural Damage |
| title_sort | role of new biomarkers functional and structural damage |
| url | http://dx.doi.org/10.1155/2013/361078 |
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