Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate Scaffold
Injectable load-bearing calcium phosphate scaffolds are synthesized using rod-like mannitol grains as porogen. These degradable injectable strong porous scaffolds, prepared by calcium phosphate cement, could represent a valid solution to achieve adequate porosity requirements while providing adequat...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2013/149261 |
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| author | Mazen Alshaaer Mohammed H. Kailani Hanan Jafar Nidaa Ababneh Abdalla Awidi |
| author_facet | Mazen Alshaaer Mohammed H. Kailani Hanan Jafar Nidaa Ababneh Abdalla Awidi |
| author_sort | Mazen Alshaaer |
| collection | DOAJ |
| description | Injectable load-bearing calcium phosphate scaffolds are synthesized using rod-like mannitol grains as porogen. These degradable injectable strong porous scaffolds, prepared by calcium phosphate cement, could represent a valid solution to achieve adequate porosity requirements while providing adequate support in load-bearing applications. The proposed process for preparing porous injectable scaffolds is as quick and versatile as conventional technologies. Using this method, porous CDHA-based calcium phosphate scaffolds with macropores sizes ranging from 70 to 300 μm, micropores ranging from 5 to 30 μm, and 30% open macroporosity were prepared. The setting time of the prepared scaffolds was 15 minutes. Also their compressive strength and e-modulus, 4.9 MPa and 400 MPa, respectively, were comparable with those of the cancellous bone. Finally, the bioactivity of the scaffolds was confirmed by cell growth with cytoplasmic extensions in the scaffolds in culture, demonstrating that the scaffold has a potential for MSC seeding and growth architecture. This combination of an interconnected macroporous structure with pore size suitable for the promotion of cell seeding and proliferation, plus adequate mechanical features, represents a porous scaffold which is a promising candidate for bone tissue engineering. |
| format | Article |
| id | doaj-art-877f1afa77b745a497faf2a4dbe367f1 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-877f1afa77b745a497faf2a4dbe367f12025-02-03T06:14:04ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422013-01-01201310.1155/2013/149261149261Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate ScaffoldMazen Alshaaer0Mohammed H. Kailani1Hanan Jafar2Nidaa Ababneh3Abdalla Awidi4Cell Therapy Center (CTC), The University of Jordan, Amman 11942, JordanCell Therapy Center (CTC), The University of Jordan, Amman 11942, JordanCell Therapy Center (CTC), The University of Jordan, Amman 11942, JordanCell Therapy Center (CTC), The University of Jordan, Amman 11942, JordanCell Therapy Center (CTC), The University of Jordan, Amman 11942, JordanInjectable load-bearing calcium phosphate scaffolds are synthesized using rod-like mannitol grains as porogen. These degradable injectable strong porous scaffolds, prepared by calcium phosphate cement, could represent a valid solution to achieve adequate porosity requirements while providing adequate support in load-bearing applications. The proposed process for preparing porous injectable scaffolds is as quick and versatile as conventional technologies. Using this method, porous CDHA-based calcium phosphate scaffolds with macropores sizes ranging from 70 to 300 μm, micropores ranging from 5 to 30 μm, and 30% open macroporosity were prepared. The setting time of the prepared scaffolds was 15 minutes. Also their compressive strength and e-modulus, 4.9 MPa and 400 MPa, respectively, were comparable with those of the cancellous bone. Finally, the bioactivity of the scaffolds was confirmed by cell growth with cytoplasmic extensions in the scaffolds in culture, demonstrating that the scaffold has a potential for MSC seeding and growth architecture. This combination of an interconnected macroporous structure with pore size suitable for the promotion of cell seeding and proliferation, plus adequate mechanical features, represents a porous scaffold which is a promising candidate for bone tissue engineering.http://dx.doi.org/10.1155/2013/149261 |
| spellingShingle | Mazen Alshaaer Mohammed H. Kailani Hanan Jafar Nidaa Ababneh Abdalla Awidi Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate Scaffold Advances in Materials Science and Engineering |
| title | Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate Scaffold |
| title_full | Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate Scaffold |
| title_fullStr | Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate Scaffold |
| title_full_unstemmed | Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate Scaffold |
| title_short | Physicochemical and Microstructural Characterization of Injectable Load-Bearing Calcium Phosphate Scaffold |
| title_sort | physicochemical and microstructural characterization of injectable load bearing calcium phosphate scaffold |
| url | http://dx.doi.org/10.1155/2013/149261 |
| work_keys_str_mv | AT mazenalshaaer physicochemicalandmicrostructuralcharacterizationofinjectableloadbearingcalciumphosphatescaffold AT mohammedhkailani physicochemicalandmicrostructuralcharacterizationofinjectableloadbearingcalciumphosphatescaffold AT hananjafar physicochemicalandmicrostructuralcharacterizationofinjectableloadbearingcalciumphosphatescaffold AT nidaaababneh physicochemicalandmicrostructuralcharacterizationofinjectableloadbearingcalciumphosphatescaffold AT abdallaawidi physicochemicalandmicrostructuralcharacterizationofinjectableloadbearingcalciumphosphatescaffold |