Exploring the Role of Tranexamic Acid in Dermatology: A literature Review
Introduction Tranexamic acid (TXA) is a synthetic plasmin inhibitor primarily used in treating bleeding disorders. However, its use in dermatology has gained increasing attention. Due to its anti-inflammatory properties and ability to inhibit tyrosinase activity, tranexamic acid has emerged as a...
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56921 |
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| author | Aleksandra Górska Natalia Gniaź Wiktor Grela Jagoda Niewiadomska Daria Furtak Dawid Tulej Natalia Marko Alicja Dziedzic Dominika Marciniuk Paulina Głogowska |
| author_facet | Aleksandra Górska Natalia Gniaź Wiktor Grela Jagoda Niewiadomska Daria Furtak Dawid Tulej Natalia Marko Alicja Dziedzic Dominika Marciniuk Paulina Głogowska |
| author_sort | Aleksandra Górska |
| collection | DOAJ |
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Introduction
Tranexamic acid (TXA) is a synthetic plasmin inhibitor primarily used in treating bleeding disorders. However, its use in dermatology has gained increasing attention. Due to its anti-inflammatory properties and ability to inhibit tyrosinase activity, tranexamic acid has emerged as a promising agent for treating pigmentary disorders and inflammatory skin conditions.
Purpose
This review aims to identify and summarize the current applications of tranexamic acid in dermatology, including its mechanisms of action, effectiveness, and safety in treating common conditions such as melasma, hyperpigmentation, rosacea, psoriasis, angioedema, and in scar and discoloration therapies.
State of Knowledge
An analysis of the existing literature highlights the growing interest in TXA’s dermatological applications. Clinical studies suggest that tranexamic acid effectively reduces hyperpigmentation and mitigates inflammation in rosacea cases. However, several studies exhibit limitations related to sample size and methodology, underscoring the need for further, more detailed research.
Conclusions
Tranexamic acid shows promising therapeutic potential in dermatology, particularly for pigmentary and inflammatory disorders. However, further research is needed to fully understand the mechanisms of TXA and its therapeutic potential, which could lead to the development of novel treatment strategies in dermatology.
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| format | Article |
| id | doaj-art-877a25fdd1954a27a6a5787c052722d0 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-877a25fdd1954a27a6a5787c052722d02025-01-31T08:17:25ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56921Exploring the Role of Tranexamic Acid in Dermatology: A literature ReviewAleksandra Górska0https://orcid.org/0009-0004-0141-2821Natalia Gniaź1https://orcid.org/0009-0008-3329-9770Wiktor Grela2https://orcid.org/0009-0000-5801-5756Jagoda Niewiadomska3https://orcid.org/0009-0003-2219-984XDaria Furtak4https://orcid.org/0000-0003-0768-9800Dawid Tulej5https://orcid.org/0000-0002-5711-3423Natalia Marko6https://orcid.org/0009-0004-7815-4592Alicja Dziedzic7https://orcid.org/0009-0001-0460-4106Dominika Marciniuk8https://orcid.org/0009-0000-0710-8485Paulina Głogowska9https://orcid.org/0009-0002-3003-4466Uniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w LublinieUniwersytet Medyczny w Lublinie Introduction Tranexamic acid (TXA) is a synthetic plasmin inhibitor primarily used in treating bleeding disorders. However, its use in dermatology has gained increasing attention. Due to its anti-inflammatory properties and ability to inhibit tyrosinase activity, tranexamic acid has emerged as a promising agent for treating pigmentary disorders and inflammatory skin conditions. Purpose This review aims to identify and summarize the current applications of tranexamic acid in dermatology, including its mechanisms of action, effectiveness, and safety in treating common conditions such as melasma, hyperpigmentation, rosacea, psoriasis, angioedema, and in scar and discoloration therapies. State of Knowledge An analysis of the existing literature highlights the growing interest in TXA’s dermatological applications. Clinical studies suggest that tranexamic acid effectively reduces hyperpigmentation and mitigates inflammation in rosacea cases. However, several studies exhibit limitations related to sample size and methodology, underscoring the need for further, more detailed research. Conclusions Tranexamic acid shows promising therapeutic potential in dermatology, particularly for pigmentary and inflammatory disorders. However, further research is needed to fully understand the mechanisms of TXA and its therapeutic potential, which could lead to the development of novel treatment strategies in dermatology. https://apcz.umk.pl/JEHS/article/view/56921tranexamic acidmelasmarosaceahyperpigmentationpsoriasisangioedema |
| spellingShingle | Aleksandra Górska Natalia Gniaź Wiktor Grela Jagoda Niewiadomska Daria Furtak Dawid Tulej Natalia Marko Alicja Dziedzic Dominika Marciniuk Paulina Głogowska Exploring the Role of Tranexamic Acid in Dermatology: A literature Review Journal of Education, Health and Sport tranexamic acid melasma rosacea hyperpigmentation psoriasis angioedema |
| title | Exploring the Role of Tranexamic Acid in Dermatology: A literature Review |
| title_full | Exploring the Role of Tranexamic Acid in Dermatology: A literature Review |
| title_fullStr | Exploring the Role of Tranexamic Acid in Dermatology: A literature Review |
| title_full_unstemmed | Exploring the Role of Tranexamic Acid in Dermatology: A literature Review |
| title_short | Exploring the Role of Tranexamic Acid in Dermatology: A literature Review |
| title_sort | exploring the role of tranexamic acid in dermatology a literature review |
| topic | tranexamic acid melasma rosacea hyperpigmentation psoriasis angioedema |
| url | https://apcz.umk.pl/JEHS/article/view/56921 |
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