Targeted co-delivery nanosystem based on methotrexate, curcumin, and PAMAM dendrimer for improvement of the therapeutic efficacy in cervical cancer

Targeted co-delivery nanosystem based on methotrexate, curcumin, and PAMAM dendrimer for improvement of the therapeutic efficacy in cervical cancer

Abstract The simultaneous administration of multiple drugs within identical nanocarriers to cancer cells or tissues can result in the effective action of drugs at reduced concentrations. In this investigation, PAMAM dendrimers (G4-PAMAM) were employed to link with methotrexate (MTX) using DCC/NHS ch...

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Bibliographic Details
Main Authors: Ayuob Aghanejad, Shiva Kheiriabad, Maryam Ghaffari, Simin Namvar Aghdash, Neda Ghafouri, Jafar Ezzati Nazhad Dolatabadi, Hashem Andishmand, Michael R. Hamblin
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Curcumin
PAMAM dendrimer
Methotrexate
Nanocomplex
Online Access:https://doi.org/10.1038/s41598-024-82074-7
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