Durvalumab induced immune-related agranulocytosis after conversion surgery in a patient with intrahepatic cholangiocarcinoma: a case report

Durvalumab induced immune-related agranulocytosis after conversion surgery in a patient with intrahepatic cholangiocarcinoma: a case report

We report a rare hematological immune-related adverse event (irAE) induced by durvalumab, an immune checkpoint inhibitor, after conversion surgery in a patient with intrahepatic cholangiocarcinoma (ICC). A 72-year-old male was admitted for recurrent ICC treatment in the posterior sector. The primary...

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Main Authors: Yoshihito Kitamura, Seiichi Shimizu, Shintaro Kuroda, Naruhiko Honmyo, Ryosuke Nakano, Hiroshi Sakai, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Tsuyoshi Kobayashi, Tatsuo Ichinohe, Hideki Ohdan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
agranulocytosis
durvalumab
immune-related adverse event
intrahepatic cholangiocarcinoma
conversion surgery
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610190/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610190/full

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