Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context
Summary: Background: To evaluate the acceptance and safety of the treatment of newborns with nirsevimab (a long-acting monoclonal antibody designed to prevent respiratory syncytial virus infections) during the first season of implementation. Methods: A longitudinal, prospective, single-centre cohor...
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Elsevier
2025-01-01
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| Series: | EClinicalMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537024005650 |
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| author | Charlotte Ocana de Sentuary Clara Testard Marion Lagrée Maxime Leroy Lisa Gasnier Alicia Enes-Dias Constance Leruste Diariatou Diallo Michael Génin Thameur Rakza François Dubos |
| author_facet | Charlotte Ocana de Sentuary Clara Testard Marion Lagrée Maxime Leroy Lisa Gasnier Alicia Enes-Dias Constance Leruste Diariatou Diallo Michael Génin Thameur Rakza François Dubos |
| author_sort | Charlotte Ocana de Sentuary |
| collection | DOAJ |
| description | Summary: Background: To evaluate the acceptance and safety of the treatment of newborns with nirsevimab (a long-acting monoclonal antibody designed to prevent respiratory syncytial virus infections) during the first season of implementation. Methods: A longitudinal, prospective, single-centre cohort study was conducted from September 18th, 2023, to January 23rd, 2024 at Lille University Hospital (Lille, France). All newborns admitted to the hospital's maternity department during the study period and whose parents agreed to participate in the study were included. Parents were asked to state whether or not they agreed for their infant to receive nirsevimab. The occurrence of adverse events (AEs) 2 h after nirsevimab treatment and 7, 14 and 30 days after discharge was documented by the mother. The primary endpoint was the nirsevimab treatment acceptance rate. The secondary endpoints were the variables associated with the acceptance of nirsevimab, the reasons for accepting or refusing nirsevimab, and the treatment's real-life safety, relative to a non-treated control group of newborns. Findings: Of the 1730 infants born in the hospital during the study period, 477 met all the inclusion criteria and were enrolled. The nirsevimab acceptance rate [95% confidence interval] was 91.6% [89.1%–94.2%]. In a multivariable analysis, the mother's age, lower parity and having a partner in work were significantly associated with nirsevimab acceptance. The most common reason for accepting treatment was “to protect my baby”, and the most common reason for refusing treatment was the lack of long-term data on nirsevimab. The nirsevimab and control groups did not differ significantly in terms of the types and frequencies of AEs. At least one serious AE was reported for 9.4% of the infants in the nirsevimab group and for 10.3% in the control group. None of the serious AEs were considered to be related to nirsevimab treatment. Interpretation: The nirsevimab acceptance rate for newborns in the maternity unit was high during the first season of implementation. The safety profile was very good, with no significant differences between the nirsevimab group and the control group. Funding: None. |
| format | Article |
| id | doaj-art-87607b1053b947d39c9f3fef84e6f8f6 |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-87607b1053b947d39c9f3fef84e6f8f62025-01-22T05:43:18ZengElsevierEClinicalMedicine2589-53702025-01-0179102986Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in contextCharlotte Ocana de Sentuary0Clara Testard1Marion Lagrée2Maxime Leroy3Lisa Gasnier4Alicia Enes-Dias5Constance Leruste6Diariatou Diallo7Michael Génin8Thameur Rakza9François Dubos10CHU Lille, Service de Pédiatrie de Maternité, Jeanne de Flandre Hospital, F-59000, Lille, FranceCHU Lille, Urgences Pédiatriques & Maladies Infectieuses, Roger Salengro Hospital, F-59000, Lille, FranceCHU Lille, Urgences Pédiatriques & Maladies Infectieuses, Roger Salengro Hospital, F-59000, Lille, FranceCHU Lille, Département de Biostatistiques, F-59000, Lille, FranceCHU Lille, Urgences Pédiatriques & Maladies Infectieuses, Roger Salengro Hospital, F-59000, Lille, FranceCHU Lille, Urgences Pédiatriques & Maladies Infectieuses, Roger Salengro Hospital, F-59000, Lille, FranceCHU Lille, Urgences Pédiatriques & Maladies Infectieuses, Roger Salengro Hospital, F-59000, Lille, FranceCHU Lille, Urgences Pédiatriques & Maladies Infectieuses, Roger Salengro Hospital, F-59000, Lille, FranceCHU Lille, Département de Biostatistiques, F-59000, Lille, France; Univ. Lille, ULR2694–METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, F-59000, Lille, FranceCHU Lille, Service de Pédiatrie de Maternité, Jeanne de Flandre Hospital, F-59000, Lille, FranceCHU Lille, Urgences Pédiatriques & Maladies Infectieuses, Roger Salengro Hospital, F-59000, Lille, France; Univ. Lille, ULR2694–METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, F-59000, Lille, France; Corresponding author. Hôpital Roger Salengro, CHU de Lille, Avenue Emile Laine, F-59000, Lille, France.Summary: Background: To evaluate the acceptance and safety of the treatment of newborns with nirsevimab (a long-acting monoclonal antibody designed to prevent respiratory syncytial virus infections) during the first season of implementation. Methods: A longitudinal, prospective, single-centre cohort study was conducted from September 18th, 2023, to January 23rd, 2024 at Lille University Hospital (Lille, France). All newborns admitted to the hospital's maternity department during the study period and whose parents agreed to participate in the study were included. Parents were asked to state whether or not they agreed for their infant to receive nirsevimab. The occurrence of adverse events (AEs) 2 h after nirsevimab treatment and 7, 14 and 30 days after discharge was documented by the mother. The primary endpoint was the nirsevimab treatment acceptance rate. The secondary endpoints were the variables associated with the acceptance of nirsevimab, the reasons for accepting or refusing nirsevimab, and the treatment's real-life safety, relative to a non-treated control group of newborns. Findings: Of the 1730 infants born in the hospital during the study period, 477 met all the inclusion criteria and were enrolled. The nirsevimab acceptance rate [95% confidence interval] was 91.6% [89.1%–94.2%]. In a multivariable analysis, the mother's age, lower parity and having a partner in work were significantly associated with nirsevimab acceptance. The most common reason for accepting treatment was “to protect my baby”, and the most common reason for refusing treatment was the lack of long-term data on nirsevimab. The nirsevimab and control groups did not differ significantly in terms of the types and frequencies of AEs. At least one serious AE was reported for 9.4% of the infants in the nirsevimab group and for 10.3% in the control group. None of the serious AEs were considered to be related to nirsevimab treatment. Interpretation: The nirsevimab acceptance rate for newborns in the maternity unit was high during the first season of implementation. The safety profile was very good, with no significant differences between the nirsevimab group and the control group. Funding: None.http://www.sciencedirect.com/science/article/pii/S2589537024005650AcceptanceNewbornNirsevimabRespiratory syncytial virusSafety |
| spellingShingle | Charlotte Ocana de Sentuary Clara Testard Marion Lagrée Maxime Leroy Lisa Gasnier Alicia Enes-Dias Constance Leruste Diariatou Diallo Michael Génin Thameur Rakza François Dubos Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context EClinicalMedicine Acceptance Newborn Nirsevimab Respiratory syncytial virus Safety |
| title | Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context |
| title_full | Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context |
| title_fullStr | Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context |
| title_full_unstemmed | Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context |
| title_short | Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context |
| title_sort | acceptance and safety of the rsv preventive treatment of newborns with nirsevimab in the maternity department a prospective longitudinal cohort study in franceresearch in context |
| topic | Acceptance Newborn Nirsevimab Respiratory syncytial virus Safety |
| url | http://www.sciencedirect.com/science/article/pii/S2589537024005650 |
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