Wound Healing Activity of <i>Arum Maculatum</i>
Objective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed to assess and determine the possible pharmacological activities of A. macula...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-03-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-73368 |
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| author | Ayse ARZU SAKUL Mehmet Evren OKUR Sule AYLA Benay DAYLAN Ayse Esra KARADAG Sebnem BATUR Ekrem Musa OZDEMIR Ebrar ALTINALAN Mehmet Yalcin GUNAL |
| author_facet | Ayse ARZU SAKUL Mehmet Evren OKUR Sule AYLA Benay DAYLAN Ayse Esra KARADAG Sebnem BATUR Ekrem Musa OZDEMIR Ebrar ALTINALAN Mehmet Yalcin GUNAL |
| author_sort | Ayse ARZU SAKUL |
| collection | DOAJ |
| description | Objective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed to assess and determine the possible pharmacological activities of A. maculatum and evaluate its potential to act as a wound care plant.
Methods: The antioxidant and antimicrobial activities of A. maculatum were investigated using excisional in vivo and in vitro wound healing mouse models. A total of 32 Balb-c mice were used, which were equally, divided into four groups: saline control group, control group, A. maculatum group, and Centella asiatica extract group. Treatment applications were performed topically once per day. Wound area narrowing, wound healing percentage, and epithelialization time were analyzed.
Results: A. maculatum application supported the healing process in in vivo and in vitro wound models. A. maculatum contributed to the healing process by promoting granulation tissue formation, epidermal regeneration, and angiogenesis.
Conclusions: Wound healing is a complex and well-organized process that requires communication between cells. The antioxidant and antimicrobial activities of A. maculatum extract have been determined by current studies. A. maculatum extract may provide significant benefits in promoting the wound healing process. |
| format | Article |
| id | doaj-art-875f9ca285174436babcdf286d16c3cb |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-875f9ca285174436babcdf286d16c3cb2025-01-30T07:05:46ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062023-03-0138181510.4274/MMJ.galenos.2022.73368MEDJ-73368Wound Healing Activity of <i>Arum Maculatum</i>Ayse ARZU SAKUL0Mehmet Evren OKUR1Sule AYLA2Benay DAYLAN3Ayse Esra KARADAG4Sebnem BATUR5Ekrem Musa OZDEMIR6Ebrar ALTINALAN7Mehmet Yalcin GUNAL8Istanbul Medipol University Faculty of Medicine, Department of Medical Pharmacology; Research Institute for Health Sciences and Technologies (SABITA), Istanbul, TurkeyUniversity of Health Sciences Faculty of Pharmacy, Department of Pharmacology, Istanbul, TurkeyIstanbul Medeniyet University Faculty of Medicine, Department of Histology and Embryology, Istanbul, TurkeyIstanbul Medipol University Faculty of Medicine, Department of Histology and Embryology, Istanbul, TurkeyIstanbul Medipol University Faculty of Pharmacy, Department of Pharmacognosy, Istanbul, TurkeyIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pathology, Istanbul, TurkeyIstanbul Medipol University, Research Institute for Health Sciences and Technologies (SABITA); Medical Research Center (MEDITAM), Istanbul, TurkeyIstanbul Medipol University Faculty of Medicine, Department of Medical Pharmacology; Research Institute for Health Sciences and Technologies (SABITA), Istanbul, TurkeyAlanya Alaaddin Keykubat University Faculty of Medicine, Department of Physiology, Antalya, TurkeyObjective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed to assess and determine the possible pharmacological activities of A. maculatum and evaluate its potential to act as a wound care plant. Methods: The antioxidant and antimicrobial activities of A. maculatum were investigated using excisional in vivo and in vitro wound healing mouse models. A total of 32 Balb-c mice were used, which were equally, divided into four groups: saline control group, control group, A. maculatum group, and Centella asiatica extract group. Treatment applications were performed topically once per day. Wound area narrowing, wound healing percentage, and epithelialization time were analyzed. Results: A. maculatum application supported the healing process in in vivo and in vitro wound models. A. maculatum contributed to the healing process by promoting granulation tissue formation, epidermal regeneration, and angiogenesis. Conclusions: Wound healing is a complex and well-organized process that requires communication between cells. The antioxidant and antimicrobial activities of A. maculatum extract have been determined by current studies. A. maculatum extract may provide significant benefits in promoting the wound healing process.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-73368a. maculatumwound healingmiceantioxidantextract |
| spellingShingle | Ayse ARZU SAKUL Mehmet Evren OKUR Sule AYLA Benay DAYLAN Ayse Esra KARADAG Sebnem BATUR Ekrem Musa OZDEMIR Ebrar ALTINALAN Mehmet Yalcin GUNAL Wound Healing Activity of <i>Arum Maculatum</i> Medeniyet Medical Journal a. maculatum wound healing mice antioxidant extract |
| title | Wound Healing Activity of <i>Arum Maculatum</i> |
| title_full | Wound Healing Activity of <i>Arum Maculatum</i> |
| title_fullStr | Wound Healing Activity of <i>Arum Maculatum</i> |
| title_full_unstemmed | Wound Healing Activity of <i>Arum Maculatum</i> |
| title_short | Wound Healing Activity of <i>Arum Maculatum</i> |
| title_sort | wound healing activity of i arum maculatum i |
| topic | a. maculatum wound healing mice antioxidant extract |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-73368 |
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