Enhancer RNAs contribute to genome reprogramming driven by a GATA3 noncoding variant in leukaemia

Enhancer RNAs contribute to genome reprogramming driven by a GATA3 noncoding variant in leukaemia

Abstract The GATA3 noncoding variant rs3824662 has been implicated in the pathogenesis of Ph-like B-ALL, where it is associated with extensive chromatin reorganisation, resulting in the dysregulation of multiple genes, including CRLF2 overexpression. Given the altered chromatin landscape and increas...

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Main Authors: Thayana da Conceição Barbosa, Caroline Pires Poubel, Ana Luiza Tardem Maciel, Caroline Barbieri Blunck, Rafael Lima dos Santos, Mariana Boroni, Marcela Braga Mansur, Mariana Emerenciano
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-10262-0
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https://doi.org/10.1038/s41598-025-10262-0

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