PPARG/SPP1/CD44 signaling pathway in alveolar macrophages: Mechanisms of lipid dysregulation and therapeutic targets in idiopathic pulmonary fibrosis

PPARG/SPP1/CD44 signaling pathway in alveolar macrophages: Mechanisms of lipid dysregulation and therapeutic targets in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. It is characterized by inflammation and fibrosis in the lung parenchyma and interstitium. Given its poor prognosis and limited treatment options, understanding the underlying molecular mechanisms is crucial....

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Bibliographic Details
Main Authors: Ganggang Li, Yuwei Zhang, Huanyu Jiang, Xuanyu Wu, Yanwei Hao, Yuchen Su, Yutong Zou, Wenjia Xian, Fei Wang, Quanyu Du
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Idiopathic pulmonary fibrosis
Lipid metabolism
Alveolar macrophage
PPARG
SPP1
CD44
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025000076
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