The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review
Malaria remains a significant global health problem, but the development of effective antimalarial drugs is challenging due to the parasite’s complex life cycle and lack of knowledge about the critical specific stages. Medicinal plants have been investigated as adjuvant therapy for malaria, so this...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/9135617 |
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| author | Shafia Khairani Nisa Fauziah Hesti Lina Wiraswati Ramdan Panigoro Endang Yuni Setyowati Afiat Berbudi |
| author_facet | Shafia Khairani Nisa Fauziah Hesti Lina Wiraswati Ramdan Panigoro Endang Yuni Setyowati Afiat Berbudi |
| author_sort | Shafia Khairani |
| collection | DOAJ |
| description | Malaria remains a significant global health problem, but the development of effective antimalarial drugs is challenging due to the parasite’s complex life cycle and lack of knowledge about the critical specific stages. Medicinal plants have been investigated as adjuvant therapy for malaria, so this systematic review summarizes 46 primary articles published until December 2020 that discuss curcumin and piperine as antimalarial agents. The selected articles discussed their antioxidant, anti-inflammatory, and antiapoptosis properties, as well as their mechanism of action against Plasmodium species. Curcumin is a potent antioxidant, damages parasite DNA, and may promote an immune response against Plasmodium by increasing reactive oxygen species (ROS), while piperine is also a potent antioxidant that potentiates the effects of curcumin. Hence, combining these compounds is likely to have the same effect as chloroquine, that is, attenuate and restrict parasite development, thereby reducing parasitemia and increasing host survival. This systematic review presents new information regarding the development of a curcumin-piperine combination for future malaria therapy. |
| format | Article |
| id | doaj-art-873bf9a5773a4fb3ad8eafa8bac74e8e |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-873bf9a5773a4fb3ad8eafa8bac74e8e2025-02-03T07:23:56ZengWileyJournal of Tropical Medicine1687-96861687-96942021-01-01202110.1155/2021/91356179135617The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic ReviewShafia Khairani0Nisa Fauziah1Hesti Lina Wiraswati2Ramdan Panigoro3Endang Yuni Setyowati4Afiat Berbudi5Doctoral Program in Medical Science, Faculty of Medicine, Padjadjaran University, Bandung, IndonesiaDepartment of Biomedical Sciences, Parasitology Division, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaDepartment of Biomedical Sciences, Parasitology Division, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaDepartment of Biomedical Sciences, Biochemistry and Molecular Biology Division, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaVeterinary Medicine Program, Faculty of Medicine, Padjadjaran University, Bandung, IndonesiaDepartment of Biomedical Sciences, Parasitology Division, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaMalaria remains a significant global health problem, but the development of effective antimalarial drugs is challenging due to the parasite’s complex life cycle and lack of knowledge about the critical specific stages. Medicinal plants have been investigated as adjuvant therapy for malaria, so this systematic review summarizes 46 primary articles published until December 2020 that discuss curcumin and piperine as antimalarial agents. The selected articles discussed their antioxidant, anti-inflammatory, and antiapoptosis properties, as well as their mechanism of action against Plasmodium species. Curcumin is a potent antioxidant, damages parasite DNA, and may promote an immune response against Plasmodium by increasing reactive oxygen species (ROS), while piperine is also a potent antioxidant that potentiates the effects of curcumin. Hence, combining these compounds is likely to have the same effect as chloroquine, that is, attenuate and restrict parasite development, thereby reducing parasitemia and increasing host survival. This systematic review presents new information regarding the development of a curcumin-piperine combination for future malaria therapy.http://dx.doi.org/10.1155/2021/9135617 |
| spellingShingle | Shafia Khairani Nisa Fauziah Hesti Lina Wiraswati Ramdan Panigoro Endang Yuni Setyowati Afiat Berbudi The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review Journal of Tropical Medicine |
| title | The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review |
| title_full | The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review |
| title_fullStr | The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review |
| title_full_unstemmed | The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review |
| title_short | The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review |
| title_sort | potential use of a curcumin piperine combination as an antimalarial agent a systematic review |
| url | http://dx.doi.org/10.1155/2021/9135617 |
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