Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications
Abstract Biomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile and innovative nanoagents due to their str...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Aggregate |
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| Online Access: | https://doi.org/10.1002/agt2.672 |
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| author | Maryam Shabbir Atia Atiq Jiahua Wang Maria Atiq Nyla Saeed Ibrahim Yildiz Xuehai Yan Ruirui Xing Manzar Abbas |
| author_facet | Maryam Shabbir Atia Atiq Jiahua Wang Maria Atiq Nyla Saeed Ibrahim Yildiz Xuehai Yan Ruirui Xing Manzar Abbas |
| author_sort | Maryam Shabbir |
| collection | DOAJ |
| description | Abstract Biomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile and innovative nanoagents due to their structure‒function control, biological nature, and simple preparation methods. This review article summarized the recent developments in multicomponent nanomaterials formed from metal coordination interactions with amino acids, peptides, and proteins, together with anticancer drugs, for cancer theranostics. We discussed the role of functional groups anchored in building blocks for coordination interactions, and subsequently, the types of interactions were examined from a structure‒function perspective. Amino acids with different metals and anticancer drugs forming supramolecular nanomaterials and their anticancer mechanisms were highlighted. Peptides with different metals and anticancer drugs, proteins with metals and anticancer drugs used for material formations, and anticancer activity have been discussed. Ultimately, the conclusion and future outlook for multicomponent supramolecular nanomaterials offer fundamental insights into fabrication design and precision medicine. |
| format | Article |
| id | doaj-art-8731854cb7a84ecf8653d0eb1d244286 |
| institution | Kabale University |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj-art-8731854cb7a84ecf8653d0eb1d2442862025-01-21T08:57:07ZengWileyAggregate2692-45602025-01-0161n/an/a10.1002/agt2.672Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applicationsMaryam Shabbir0Atia Atiq1Jiahua Wang2Maria Atiq3Nyla Saeed4Ibrahim Yildiz5Xuehai Yan6Ruirui Xing7Manzar Abbas8Institute of Physics The Islamia University of Bahawalpur Bahawalpur PakistanDivision of Science and Technology Department of Physics University of Education Lahore PakistanDepartment of Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai ChinaInstitute of Physics The Islamia University of Bahawalpur Bahawalpur PakistanInstitute of Physics The Islamia University of Bahawalpur Bahawalpur PakistanDepartment of Chemistry Khalifa University of Science and Technology Abu Dhabi United Arab EmiratesUniversity of Chinese Academy of Sciences Beijing ChinaUniversity of Chinese Academy of Sciences Beijing ChinaDepartment of Chemistry Khalifa University of Science and Technology Abu Dhabi United Arab EmiratesAbstract Biomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile and innovative nanoagents due to their structure‒function control, biological nature, and simple preparation methods. This review article summarized the recent developments in multicomponent nanomaterials formed from metal coordination interactions with amino acids, peptides, and proteins, together with anticancer drugs, for cancer theranostics. We discussed the role of functional groups anchored in building blocks for coordination interactions, and subsequently, the types of interactions were examined from a structure‒function perspective. Amino acids with different metals and anticancer drugs forming supramolecular nanomaterials and their anticancer mechanisms were highlighted. Peptides with different metals and anticancer drugs, proteins with metals and anticancer drugs used for material formations, and anticancer activity have been discussed. Ultimately, the conclusion and future outlook for multicomponent supramolecular nanomaterials offer fundamental insights into fabrication design and precision medicine.https://doi.org/10.1002/agt2.672anticancer therapydiagnosticsmetal‐peptidesself‐assemblysupramolecular nanomaterials |
| spellingShingle | Maryam Shabbir Atia Atiq Jiahua Wang Maria Atiq Nyla Saeed Ibrahim Yildiz Xuehai Yan Ruirui Xing Manzar Abbas Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications Aggregate anticancer therapy diagnostics metal‐peptides self‐assembly supramolecular nanomaterials |
| title | Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications |
| title_full | Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications |
| title_fullStr | Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications |
| title_full_unstemmed | Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications |
| title_short | Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications |
| title_sort | metal coordinated amino acid peptide protein based supramolecular self assembled nanomaterials for anticancer applications |
| topic | anticancer therapy diagnostics metal‐peptides self‐assembly supramolecular nanomaterials |
| url | https://doi.org/10.1002/agt2.672 |
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