Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review
<b>Background:</b> The prevalence of hepatitis B virus infection remains high in the Democratic Republic of Congo (DRC), constituting a public health problem in view of the fatal complications it causes, notably cirrhosis and hepatocellular carcinoma. The aim of this study was to provide...
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| author | Marcellin Mengouo Nimpa Hermès Karemere Christian Ngandu Franck-Fortune Mboussou M. Carolina Danovaro-Holliday Dalau Nkamba André Bita Fouda Bienvenu Nguejio Sifa Kakozi Aimé Mwana-Wabene Cikomola Jean-Crispin Mukendi Dieudonné Mwamba Moise Désiré Yapi Richard Bahizire Riziki Cedric Mwanga John Otomba Jean Baptiste Nikiema Boureima Hama Sambo Daniel Katuashi Ishoso |
| author_facet | Marcellin Mengouo Nimpa Hermès Karemere Christian Ngandu Franck-Fortune Mboussou M. Carolina Danovaro-Holliday Dalau Nkamba André Bita Fouda Bienvenu Nguejio Sifa Kakozi Aimé Mwana-Wabene Cikomola Jean-Crispin Mukendi Dieudonné Mwamba Moise Désiré Yapi Richard Bahizire Riziki Cedric Mwanga John Otomba Jean Baptiste Nikiema Boureima Hama Sambo Daniel Katuashi Ishoso |
| author_sort | Marcellin Mengouo Nimpa |
| collection | DOAJ |
| description | <b>Background:</b> The prevalence of hepatitis B virus infection remains high in the Democratic Republic of Congo (DRC), constituting a public health problem in view of the fatal complications it causes, notably cirrhosis and hepatocellular carcinoma. The aim of this study was to provide an overview of the situation of viral hepatitis B in the DRC and in particular its implications for public health. <b>Methods:</b> A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) group guidelines. Google Scholar, PubMed, and ResearchGate were used as databases. The review essentially analyzed the viral hepatitis B (HBV) vaccination status of study subjects, diagnostic means, HBV genotypes in DR Congo, seroprevalence of HBV infection, subjects’ level of knowledge and perceptions of HBV, co-infection/comorbidity with HBV infection, factors associated with HBV infection and public health issues raised by HBV infection. <b>Results:</b> The vast majority of studies (69%) were carried out to determine the seroprevalence of HBV infection. The Determine rapid test was the most widely used test (10 studies), sometimes combined with ELISA (3 studies) and polymerase chain reaction (PCR) (1 study, for genotyping). Some of the public health issues raised by hepatitis B virus infection were identified in the course of the included studies, in relation to co-infection, comorbidity, associated factors, and individuals’ level of knowledge and perceptions of HBV. Certain factors were identified as being closely associated with HBV, notably healthcare professions (e.g., doctor, laboratory technician) and having several sexual partners. In terms of perception of HBV, the hepatitis B virus is recognized as dangerous, and the majority of people questioned in the various studies were aware that vaccination remains the most effective means of prevention. <b>Conclusions:</b> Hepatitis B is a highly contagious infectious disease present in the DRC, with a higher prevalence among healthcare professionals, sex workers, patients with certain diseases including HIV, and people with a history of blood transfusion. The surveillance system within the national blood transfusion program needs to be strengthened. Raising public awareness of the seriousness of viral hepatitis B, offering vaccination to at-risk populations, and systematically screening pregnant women and blood donors for HBV infection could help reduce the prevalence of viral hepatitis B. |
| format | Article |
| id | doaj-art-8716da928f67455abd4dc583c72172ab |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-8716da928f67455abd4dc583c72172ab2025-01-24T13:52:14ZengMDPI AGViruses1999-49152024-12-01171910.3390/v17010009Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic ReviewMarcellin Mengouo Nimpa0Hermès Karemere1Christian Ngandu2Franck-Fortune Mboussou3M. Carolina Danovaro-Holliday4Dalau Nkamba5André Bita Fouda6Bienvenu Nguejio7Sifa Kakozi8Aimé Mwana-Wabene Cikomola9Jean-Crispin Mukendi10Dieudonné Mwamba11Moise Désiré Yapi12Richard Bahizire Riziki13Cedric Mwanga14John Otomba15Jean Baptiste Nikiema16Boureima Hama Sambo17Daniel Katuashi Ishoso18World Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoÉcole Régionale de Santé Publique, Université Catholique de Bukavu, Bukavu 11103, Democratic Republic of the CongoNational Institute of Public Health, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization African Regional Office, Brazzaville P.O. Box 06, CongoImmunization, Analytics and Insights (IAI), Department of Immunization, Vaccines and Biologicals (IVB), World Health Organization (WHO), 1211 Geneva, SwitzerlandKinshasa School of Public Health, University of Kinshasa, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization African Regional Office, Brazzaville P.O. Box 06, CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoExpanded Program of Immunization, Kinshasa 01206, Democratic Republic of the CongoExpanded Program of Immunization, Kinshasa 01206, Democratic Republic of the CongoNational Institute of Public Health, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the CongoWorld Health Organization (WHO) Country Office, Kinshasa 01206, Democratic Republic of the Congo<b>Background:</b> The prevalence of hepatitis B virus infection remains high in the Democratic Republic of Congo (DRC), constituting a public health problem in view of the fatal complications it causes, notably cirrhosis and hepatocellular carcinoma. The aim of this study was to provide an overview of the situation of viral hepatitis B in the DRC and in particular its implications for public health. <b>Methods:</b> A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) group guidelines. Google Scholar, PubMed, and ResearchGate were used as databases. The review essentially analyzed the viral hepatitis B (HBV) vaccination status of study subjects, diagnostic means, HBV genotypes in DR Congo, seroprevalence of HBV infection, subjects’ level of knowledge and perceptions of HBV, co-infection/comorbidity with HBV infection, factors associated with HBV infection and public health issues raised by HBV infection. <b>Results:</b> The vast majority of studies (69%) were carried out to determine the seroprevalence of HBV infection. The Determine rapid test was the most widely used test (10 studies), sometimes combined with ELISA (3 studies) and polymerase chain reaction (PCR) (1 study, for genotyping). Some of the public health issues raised by hepatitis B virus infection were identified in the course of the included studies, in relation to co-infection, comorbidity, associated factors, and individuals’ level of knowledge and perceptions of HBV. Certain factors were identified as being closely associated with HBV, notably healthcare professions (e.g., doctor, laboratory technician) and having several sexual partners. In terms of perception of HBV, the hepatitis B virus is recognized as dangerous, and the majority of people questioned in the various studies were aware that vaccination remains the most effective means of prevention. <b>Conclusions:</b> Hepatitis B is a highly contagious infectious disease present in the DRC, with a higher prevalence among healthcare professionals, sex workers, patients with certain diseases including HIV, and people with a history of blood transfusion. The surveillance system within the national blood transfusion program needs to be strengthened. Raising public awareness of the seriousness of viral hepatitis B, offering vaccination to at-risk populations, and systematically screening pregnant women and blood donors for HBV infection could help reduce the prevalence of viral hepatitis B.https://www.mdpi.com/1999-4915/17/1/9Democratic Republic of the Congoviral hepatitis Bpublic health |
| spellingShingle | Marcellin Mengouo Nimpa Hermès Karemere Christian Ngandu Franck-Fortune Mboussou M. Carolina Danovaro-Holliday Dalau Nkamba André Bita Fouda Bienvenu Nguejio Sifa Kakozi Aimé Mwana-Wabene Cikomola Jean-Crispin Mukendi Dieudonné Mwamba Moise Désiré Yapi Richard Bahizire Riziki Cedric Mwanga John Otomba Jean Baptiste Nikiema Boureima Hama Sambo Daniel Katuashi Ishoso Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review Viruses Democratic Republic of the Congo viral hepatitis B public health |
| title | Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review |
| title_full | Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review |
| title_fullStr | Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review |
| title_full_unstemmed | Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review |
| title_short | Viral Hepatitis B and Its Implications for Public Health in DR Congo: A Systematic Review |
| title_sort | viral hepatitis b and its implications for public health in dr congo a systematic review |
| topic | Democratic Republic of the Congo viral hepatitis B public health |
| url | https://www.mdpi.com/1999-4915/17/1/9 |
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