The functions of herpesvirus shuttling proteins in the virus lifecycle
During viral infection, the transport of various proteins between the nucleus and cytoplasm plays an important role in the viral lifecycle. Shuttling proteins are key factors in the transmission of nucleocytoplasmic information within cells and usually contain nuclear localization signals and nuclea...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1515241/full |
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| author | Huijun Cao Huijun Cao Huijun Cao Huijun Cao Huijun Cao Mingshu Wang Mingshu Wang Mingshu Wang Mingshu Wang Mingshu Wang Anchun Cheng Anchun Cheng Anchun Cheng Anchun Cheng Anchun Cheng Bin Tian Bin Tian Bin Tian Bin Tian Bin Tian Qiao Yang Qiao Yang Qiao Yang Qiao Yang Qiao Yang Xumin Ou Xumin Ou Xumin Ou Xumin Ou Xumin Ou Di Sun Di Sun Di Sun Di Sun Di Sun Yu He Yu He Yu He Yu He Yu He Zhen Wu Zhen Wu Zhen Wu Zhen Wu Zhen Wu Xinxin Zhao Xinxin Zhao Xinxin Zhao Xinxin Zhao Xinxin Zhao Ying Wu Ying Wu Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Juan Huang Juan Huang YanLing Yu Ling Zhang Shun Chen Shun Chen Shun Chen Shun Chen Shun Chen Mafeng Liu Mafeng Liu Mafeng Liu Mafeng Liu Mafeng Liu Dekang Zhu Dekang Zhu Dekang Zhu Dekang Zhu Renyong Jia Renyong Jia Renyong Jia Renyong Jia Renyong Jia |
| author_facet | Huijun Cao Huijun Cao Huijun Cao Huijun Cao Huijun Cao Mingshu Wang Mingshu Wang Mingshu Wang Mingshu Wang Mingshu Wang Anchun Cheng Anchun Cheng Anchun Cheng Anchun Cheng Anchun Cheng Bin Tian Bin Tian Bin Tian Bin Tian Bin Tian Qiao Yang Qiao Yang Qiao Yang Qiao Yang Qiao Yang Xumin Ou Xumin Ou Xumin Ou Xumin Ou Xumin Ou Di Sun Di Sun Di Sun Di Sun Di Sun Yu He Yu He Yu He Yu He Yu He Zhen Wu Zhen Wu Zhen Wu Zhen Wu Zhen Wu Xinxin Zhao Xinxin Zhao Xinxin Zhao Xinxin Zhao Xinxin Zhao Ying Wu Ying Wu Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Juan Huang Juan Huang YanLing Yu Ling Zhang Shun Chen Shun Chen Shun Chen Shun Chen Shun Chen Mafeng Liu Mafeng Liu Mafeng Liu Mafeng Liu Mafeng Liu Dekang Zhu Dekang Zhu Dekang Zhu Dekang Zhu Renyong Jia Renyong Jia Renyong Jia Renyong Jia Renyong Jia |
| author_sort | Huijun Cao |
| collection | DOAJ |
| description | During viral infection, the transport of various proteins between the nucleus and cytoplasm plays an important role in the viral lifecycle. Shuttling proteins are key factors in the transmission of nucleocytoplasmic information within cells and usually contain nuclear localization signals and nuclear export signals to mediate correct positioning for themselves and other proteins. The nucleocytoplasmic transport process is carried out through the nuclear pore complex on the nuclear envelope and is mediated by specific protein carriers. The viral proteins that function through nucleocytoplasmic shuttling in herpesviruses have gradually been identified as research advances. This article provides an overview of how shuttling proteins utilize nucleocytoplasmic shuttling signals and nuclear transport receptors for nucleocytoplasmic transport, as well as discusses how herpesvirus shuttling proteins enhance the effective infection of viruses by affecting their lifecycle and participating in innate immunity, this review provides a reference for understanding the pathogenesis of herpesvirus infection and determining new antiviral strategies. |
| format | Article |
| id | doaj-art-87121ff7ef1b4e0c859c3646b61a0f5c |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-87121ff7ef1b4e0c859c3646b61a0f5c2025-02-05T17:17:41ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.15152411515241The functions of herpesvirus shuttling proteins in the virus lifecycleHuijun Cao0Huijun Cao1Huijun Cao2Huijun Cao3Huijun Cao4Mingshu Wang5Mingshu Wang6Mingshu Wang7Mingshu Wang8Mingshu Wang9Anchun Cheng10Anchun Cheng11Anchun Cheng12Anchun Cheng13Anchun Cheng14Bin Tian15Bin Tian16Bin Tian17Bin Tian18Bin Tian19Qiao Yang20Qiao Yang21Qiao Yang22Qiao Yang23Qiao Yang24Xumin Ou25Xumin Ou26Xumin Ou27Xumin Ou28Xumin Ou29Di Sun30Di Sun31Di Sun32Di Sun33Di Sun34Yu He35Yu He36Yu He37Yu He38Yu He39Zhen Wu40Zhen Wu41Zhen Wu42Zhen Wu43Zhen Wu44Xinxin Zhao45Xinxin Zhao46Xinxin Zhao47Xinxin Zhao48Xinxin Zhao49Ying Wu50Ying Wu51Ying Wu52Ying Wu53Ying Wu54Shaqiu Zhang55Shaqiu Zhang56Shaqiu Zhang57Shaqiu Zhang58Shaqiu Zhang59Juan Huang60Juan Huang61Juan Huang62Juan Huang63Juan Huang64YanLing Yu65Ling Zhang66Shun Chen67Shun Chen68Shun Chen69Shun Chen70Shun Chen71Mafeng Liu72Mafeng Liu73Mafeng Liu74Mafeng Liu75Mafeng Liu76Dekang Zhu77Dekang Zhu78Dekang Zhu79Dekang Zhu80Renyong Jia81Renyong Jia82Renyong Jia83Renyong Jia84Renyong Jia85Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaEngineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, ChinaInternational Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu, ChinaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaDuring viral infection, the transport of various proteins between the nucleus and cytoplasm plays an important role in the viral lifecycle. Shuttling proteins are key factors in the transmission of nucleocytoplasmic information within cells and usually contain nuclear localization signals and nuclear export signals to mediate correct positioning for themselves and other proteins. The nucleocytoplasmic transport process is carried out through the nuclear pore complex on the nuclear envelope and is mediated by specific protein carriers. The viral proteins that function through nucleocytoplasmic shuttling in herpesviruses have gradually been identified as research advances. This article provides an overview of how shuttling proteins utilize nucleocytoplasmic shuttling signals and nuclear transport receptors for nucleocytoplasmic transport, as well as discusses how herpesvirus shuttling proteins enhance the effective infection of viruses by affecting their lifecycle and participating in innate immunity, this review provides a reference for understanding the pathogenesis of herpesvirus infection and determining new antiviral strategies.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1515241/fullherpesvirusshuttling proteinsnuclear localization signalnuclear export signallife cycleinnate immune escape |
| spellingShingle | Huijun Cao Huijun Cao Huijun Cao Huijun Cao Huijun Cao Mingshu Wang Mingshu Wang Mingshu Wang Mingshu Wang Mingshu Wang Anchun Cheng Anchun Cheng Anchun Cheng Anchun Cheng Anchun Cheng Bin Tian Bin Tian Bin Tian Bin Tian Bin Tian Qiao Yang Qiao Yang Qiao Yang Qiao Yang Qiao Yang Xumin Ou Xumin Ou Xumin Ou Xumin Ou Xumin Ou Di Sun Di Sun Di Sun Di Sun Di Sun Yu He Yu He Yu He Yu He Yu He Zhen Wu Zhen Wu Zhen Wu Zhen Wu Zhen Wu Xinxin Zhao Xinxin Zhao Xinxin Zhao Xinxin Zhao Xinxin Zhao Ying Wu Ying Wu Ying Wu Ying Wu Ying Wu Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Shaqiu Zhang Juan Huang Juan Huang Juan Huang Juan Huang Juan Huang YanLing Yu Ling Zhang Shun Chen Shun Chen Shun Chen Shun Chen Shun Chen Mafeng Liu Mafeng Liu Mafeng Liu Mafeng Liu Mafeng Liu Dekang Zhu Dekang Zhu Dekang Zhu Dekang Zhu Renyong Jia Renyong Jia Renyong Jia Renyong Jia Renyong Jia The functions of herpesvirus shuttling proteins in the virus lifecycle Frontiers in Microbiology herpesvirus shuttling proteins nuclear localization signal nuclear export signal life cycle innate immune escape |
| title | The functions of herpesvirus shuttling proteins in the virus lifecycle |
| title_full | The functions of herpesvirus shuttling proteins in the virus lifecycle |
| title_fullStr | The functions of herpesvirus shuttling proteins in the virus lifecycle |
| title_full_unstemmed | The functions of herpesvirus shuttling proteins in the virus lifecycle |
| title_short | The functions of herpesvirus shuttling proteins in the virus lifecycle |
| title_sort | functions of herpesvirus shuttling proteins in the virus lifecycle |
| topic | herpesvirus shuttling proteins nuclear localization signal nuclear export signal life cycle innate immune escape |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1515241/full |
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