NK/T-cell bone lymphoma-induced hemophagocytic lymphohistiocytosis: A clinical case report

Hemophagocytic lymphohistiocytosis (HLH) is a severe condition characterized by the secretion of large amounts of inflammatory cytokines. Lymphoma is a major cause of secondary HLH. This report describes the case of a child initially diagnosed with HLH who experienced recurrent episodes after treatm...

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Bibliographic Details
Main Authors: Zhanrong Zhang, MM, Feng Chen, MD
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Radiology Case Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S1930043325002365
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Summary:Hemophagocytic lymphohistiocytosis (HLH) is a severe condition characterized by the secretion of large amounts of inflammatory cytokines. Lymphoma is a major cause of secondary HLH. This report describes the case of a child initially diagnosed with HLH who experienced recurrent episodes after treatment. Ten months after the initial diagnosis, a mass was discovered in the right upper limb, and pathology findings confirmed NK/T-cell lymphoma. Based on the patient's medical history, this lymphoma was considered the underlying cause of HLH. Patients diagnosed with lymphoma complicated by HLH have a worse prognosis and shorter survival compared with those without HLH. Early diagnosis and timely symptomatic treatment can significantly improve patient prognosis.
ISSN:1930-0433