Reorganization of gray matter networks in patients with Moyamoya disease
Abstract Patients with Moyamoya disease (MMD) exhibit significant alterations in brain structure and function, but knowledge regarding gray matter networks is limited. The study enrolled 136 MMD patients and 99 healthy controls (HCs). Clinical characteristics and gray matter network topology were an...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86553-3 |
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| author | Huan Zhu Peijiong Wang Wenjie Li Qihang Zhang Chenyu Zhu Tong Liu Tao Yu Xingju Liu Qian Zhang Jizong Zhao Yan Zhang |
| author_facet | Huan Zhu Peijiong Wang Wenjie Li Qihang Zhang Chenyu Zhu Tong Liu Tao Yu Xingju Liu Qian Zhang Jizong Zhao Yan Zhang |
| author_sort | Huan Zhu |
| collection | DOAJ |
| description | Abstract Patients with Moyamoya disease (MMD) exhibit significant alterations in brain structure and function, but knowledge regarding gray matter networks is limited. The study enrolled 136 MMD patients and 99 healthy controls (HCs). Clinical characteristics and gray matter network topology were analyzed. Compared to HCs, MMD patients exhibited decreased clustering coefficient (Cp) (P = 0.006) and local efficiency (Eloc) (P = 0.013). Ischemic patients showed decreased Eloc and increased characteristic path length (Lp) compared to asymptomatic and hemorrhagic patients (P < 0.001, Bonferroni corrected). MMD patients had significant regional abnormalities, including decreased degree centrality (DC) in the left medial orbital superior frontal gyrus, left orbital inferior frontal gyrus, and right calcarine fissure and surrounding cortex (P < 0.05, FDR corrected). Increased DC was found in bilateral olfactory regions, with higher betweenness centrality (BC) in the right median cingulate, paracingulate fusiform gyrus, and left pallidum (P < 0.05, FDR corrected). Ischemic patients had lower BC in the right hippocampus compared to hemorrhagic patients, while hemorrhagic patients had decreased DC in the right triangular part of the inferior frontal gyrus compared to asymptomatic patients (P < 0.05, Bonferroni corrected). Subnetworks related to MMD and white matter hyperintensity volume were identified. There is significant reorganization of gray matter networks in patients compared to HCs, and among different types of patients. Gray matter networks can effectively detect MMD-related brain structural changes. |
| format | Article |
| id | doaj-art-86d1dd259707458b8674562b1b75f44d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-86d1dd259707458b8674562b1b75f44d2025-01-26T12:27:30ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-86553-3Reorganization of gray matter networks in patients with Moyamoya diseaseHuan Zhu0Peijiong Wang1Wenjie Li2Qihang Zhang3Chenyu Zhu4Tong Liu5Tao Yu6Xingju Liu7Qian Zhang8Jizong Zhao9Yan Zhang10Beijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityBeijing Neurosurgical Institute, Capital Medical UniversityAbstract Patients with Moyamoya disease (MMD) exhibit significant alterations in brain structure and function, but knowledge regarding gray matter networks is limited. The study enrolled 136 MMD patients and 99 healthy controls (HCs). Clinical characteristics and gray matter network topology were analyzed. Compared to HCs, MMD patients exhibited decreased clustering coefficient (Cp) (P = 0.006) and local efficiency (Eloc) (P = 0.013). Ischemic patients showed decreased Eloc and increased characteristic path length (Lp) compared to asymptomatic and hemorrhagic patients (P < 0.001, Bonferroni corrected). MMD patients had significant regional abnormalities, including decreased degree centrality (DC) in the left medial orbital superior frontal gyrus, left orbital inferior frontal gyrus, and right calcarine fissure and surrounding cortex (P < 0.05, FDR corrected). Increased DC was found in bilateral olfactory regions, with higher betweenness centrality (BC) in the right median cingulate, paracingulate fusiform gyrus, and left pallidum (P < 0.05, FDR corrected). Ischemic patients had lower BC in the right hippocampus compared to hemorrhagic patients, while hemorrhagic patients had decreased DC in the right triangular part of the inferior frontal gyrus compared to asymptomatic patients (P < 0.05, Bonferroni corrected). Subnetworks related to MMD and white matter hyperintensity volume were identified. There is significant reorganization of gray matter networks in patients compared to HCs, and among different types of patients. Gray matter networks can effectively detect MMD-related brain structural changes.https://doi.org/10.1038/s41598-025-86553-3Moyamoya DiseaseGray Matter NetworkGraph theoryGray Matter volumeNetwork-based statistic |
| spellingShingle | Huan Zhu Peijiong Wang Wenjie Li Qihang Zhang Chenyu Zhu Tong Liu Tao Yu Xingju Liu Qian Zhang Jizong Zhao Yan Zhang Reorganization of gray matter networks in patients with Moyamoya disease Scientific Reports Moyamoya Disease Gray Matter Network Graph theory Gray Matter volume Network-based statistic |
| title | Reorganization of gray matter networks in patients with Moyamoya disease |
| title_full | Reorganization of gray matter networks in patients with Moyamoya disease |
| title_fullStr | Reorganization of gray matter networks in patients with Moyamoya disease |
| title_full_unstemmed | Reorganization of gray matter networks in patients with Moyamoya disease |
| title_short | Reorganization of gray matter networks in patients with Moyamoya disease |
| title_sort | reorganization of gray matter networks in patients with moyamoya disease |
| topic | Moyamoya Disease Gray Matter Network Graph theory Gray Matter volume Network-based statistic |
| url | https://doi.org/10.1038/s41598-025-86553-3 |
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