Glutamine potentiates cefoperazone-sulbactam activity against Pseudomonas aeruginosa by increasing membrane permeability and cellular uptake

Glutamine potentiates cefoperazone-sulbactam activity against Pseudomonas aeruginosa by increasing membrane permeability and cellular uptake

PurposesThe combination of an antibiotic with a metabolic reprogramming agent is anticipated to emerge as a promising therapeutic strategy against antibiotic-resistant bacteria, though this hypothesis requires validation through preclinical pharmacodynamic studies.MethodsThis study evaluated the pre...

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Main Authors: Jiao Xiang, Xin Wang, Huiyin Lin, Lifen Yang, Xiaoxia Huang, Yuetao Chen, Yingyue Zeng, Shaohua Li, Xianliang Zhao, Shiwen Wang, Yuan Tao, Huanzhe Fu, Zhengqi Shi, Kuihai Wu, Xuanxian Peng, Hui Li, Jin Tang, Zhuanggui Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiology
Subjects:
preclinical pharmacodynamics
cefoperazone/sulbactam
multidrug resistance
carbapenem resistance
glutamine
Pseudomonas aeruginosa
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1631646/full
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