Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile
Forty-eight patients were subdivided according to C-reactive protein (CRP) levels, resulting in 19 patients with normal (2.8 ± 2.8 mg/L) and 29 with elevated (82.2 ± 76.2 mg/L) CRP levels. The elevated CRP group had iron and red blood cell (RBC) profiles characteristic of chronic immune stimulation...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/716301 |
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| author | A. M. Koorts P. F. Levay P. J. Becker M. Viljoen |
| author_facet | A. M. Koorts P. F. Levay P. J. Becker M. Viljoen |
| author_sort | A. M. Koorts |
| collection | DOAJ |
| description | Forty-eight patients were subdivided according to C-reactive protein (CRP) levels, resulting in 19 patients with normal (2.8 ± 2.8 mg/L) and 29 with elevated (82.2 ± 76.2 mg/L) CRP levels. The elevated CRP group had iron and red blood cell (RBC) profiles characteristic of chronic immune stimulation (CIS), and the normal CRP group, profiles of true iron deficiency. Normal relationships between storage iron, bioavailable iron, and RBC indices were absent in the elevated CRP group—implying the role of iron as major determinant of the RBC profile to be diminished during CIS. The elevated CRP group had significant increases in proinflammatory cytokines (INF-γ, TNF-α, Il-1β, Il-6, and Il-8). Anti-inflammatory cytokine levels were normal, except for Il-10, supporting previous indications that Il-10 contributes to reducing bioavailable iron. Regression analysis suggested decreases in transferrin to be related to increases in Il-8 and an increase in ferritin to be related to a decrease in Il-12 levels. TGF-β levels were positively related to transferrin and negatively to ferritin. |
| format | Article |
| id | doaj-art-86c50ca63134446fb4b8ba4582644a4b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-86c50ca63134446fb4b8ba4582644a4b2025-02-03T05:57:36ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/716301716301Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell ProfileA. M. Koorts0P. F. Levay1P. J. Becker2M. Viljoen3Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, P.O. Box 2034, Pretoria 0001, South AfricaDepartment of Internal Medicine, Kalafong Hospital, University of Pretoria, Pretoria 0001, South AfricaDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, P.O. Box 2034, Pretoria 0001, South AfricaDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, P.O. Box 2034, Pretoria 0001, South AfricaForty-eight patients were subdivided according to C-reactive protein (CRP) levels, resulting in 19 patients with normal (2.8 ± 2.8 mg/L) and 29 with elevated (82.2 ± 76.2 mg/L) CRP levels. The elevated CRP group had iron and red blood cell (RBC) profiles characteristic of chronic immune stimulation (CIS), and the normal CRP group, profiles of true iron deficiency. Normal relationships between storage iron, bioavailable iron, and RBC indices were absent in the elevated CRP group—implying the role of iron as major determinant of the RBC profile to be diminished during CIS. The elevated CRP group had significant increases in proinflammatory cytokines (INF-γ, TNF-α, Il-1β, Il-6, and Il-8). Anti-inflammatory cytokine levels were normal, except for Il-10, supporting previous indications that Il-10 contributes to reducing bioavailable iron. Regression analysis suggested decreases in transferrin to be related to increases in Il-8 and an increase in ferritin to be related to a decrease in Il-12 levels. TGF-β levels were positively related to transferrin and negatively to ferritin.http://dx.doi.org/10.1155/2011/716301 |
| spellingShingle | A. M. Koorts P. F. Levay P. J. Becker M. Viljoen Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile Mediators of Inflammation |
| title | Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile |
| title_full | Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile |
| title_fullStr | Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile |
| title_full_unstemmed | Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile |
| title_short | Pro- and Anti-Inflammatory Cytokines during Immune Stimulation: Modulation of Iron Status and Red Blood Cell Profile |
| title_sort | pro and anti inflammatory cytokines during immune stimulation modulation of iron status and red blood cell profile |
| url | http://dx.doi.org/10.1155/2011/716301 |
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