Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits
The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression press...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0019 |
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| author | Franc Aleš Kurhajec Slavomir Pavloková Sylvie Sabadková Dana Muselík Jan |
| author_facet | Franc Aleš Kurhajec Slavomir Pavloková Sylvie Sabadková Dana Muselík Jan |
| author_sort | Franc Aleš |
| collection | DOAJ |
| description | The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH). |
| format | Article |
| id | doaj-art-86bea5158a6f4d4a96ab81892d4a8634 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-86bea5158a6f4d4a96ab81892d4a86342025-02-02T19:57:23ZengSciendoActa Pharmaceutica1846-95582017-06-0167218720210.1515/acph-2017-0019acph-2017-0019Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruitsFranc Aleš0Kurhajec Slavomir1Pavloková Sylvie2Sabadková Dana3Muselík Jan4Department of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech RepublicDepartment of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech RepublicDepartment of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech RepublicDepartment of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech RepublicDepartment of Pharmaceutics University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech RepublicThe aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel® PH 101 and Avicel® PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel® PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets even after storage under accelerated stability conditions (6 months, 40 °C and 75 % RH).https://doi.org/10.1515/acph-2017-0019cornus masmicrocrystalline cellulosedirect compressionaccelerated stabilityprincipal component analysis |
| spellingShingle | Franc Aleš Kurhajec Slavomir Pavloková Sylvie Sabadková Dana Muselík Jan Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits Acta Pharmaceutica cornus mas microcrystalline cellulose direct compression accelerated stability principal component analysis |
| title | Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits |
| title_full | Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits |
| title_fullStr | Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits |
| title_full_unstemmed | Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits |
| title_short | Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits |
| title_sort | influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing cornelian cherry fruits |
| topic | cornus mas microcrystalline cellulose direct compression accelerated stability principal component analysis |
| url | https://doi.org/10.1515/acph-2017-0019 |
| work_keys_str_mv | AT francales influenceofconcentrationandtypeofmicrocrystallinecelluloseonthephysicalpropertiesoftabletscontainingcorneliancherryfruits AT kurhajecslavomir influenceofconcentrationandtypeofmicrocrystallinecelluloseonthephysicalpropertiesoftabletscontainingcorneliancherryfruits AT pavlokovasylvie influenceofconcentrationandtypeofmicrocrystallinecelluloseonthephysicalpropertiesoftabletscontainingcorneliancherryfruits AT sabadkovadana influenceofconcentrationandtypeofmicrocrystallinecelluloseonthephysicalpropertiesoftabletscontainingcorneliancherryfruits AT muselikjan influenceofconcentrationandtypeofmicrocrystallinecelluloseonthephysicalpropertiesoftabletscontainingcorneliancherryfruits |