Association of cadmium, lead and mercury with paraoxonase 1 activity in women.
<h4>Background</h4>The activity of paraoxonase 1 (PON1), an antioxidant enzyme whose polymorphisms have been associated with cancer risk, may be associated with metals exposure.<h4>Objective</h4>To evaluate PON1 activity in relation to cadmium, lead, and mercury levels in hea...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092152&type=printable |
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| author | Anna Z Pollack Lindsey Sjaarda Katherine A Ahrens Sunni L Mumford Richard W Browne Jean Wactawski-Wende Enrique F Schisterman |
| author_facet | Anna Z Pollack Lindsey Sjaarda Katherine A Ahrens Sunni L Mumford Richard W Browne Jean Wactawski-Wende Enrique F Schisterman |
| author_sort | Anna Z Pollack |
| collection | DOAJ |
| description | <h4>Background</h4>The activity of paraoxonase 1 (PON1), an antioxidant enzyme whose polymorphisms have been associated with cancer risk, may be associated with metals exposure.<h4>Objective</h4>To evaluate PON1 activity in relation to cadmium, lead, and mercury levels in healthy, premenopausal women.<h4>Methods</h4>Women from upstate New York were followed for ≥ two menstrual cycles. Repeated measures linear mixed models estimated the association between cadmium, lead, and mercury levels (by tertile: T1, T2, T3) and PON1 arylesterase (PON1A) and PON1 paraoxonase (PON1P) activity, separately. Analyses were stratified by PON1 Q192R phenotype and un-stratified.<h4>Results</h4>Median blood cadmium, lead, and mercury concentrations were 0.30 µg/L, 0.87 µg/dL, and 1.15 µg/L. In un-stratified analyses cadmium and mercury were associated with decreased PON1A activity (T2 vs. T1; not T3 vs. T1) but metals were not associated with PON1P. Phenotypes were distributed between QQ (n = 99), QR (n = 117), and RR (n = 34). Cadmium was associated with decreased PON1A activity for QR and RR phenotypes comparing T2 vs. T1 (-14.4% 95% confidence interval [CI] [-20.1, -8.4] and -27.9% [-39.5, -14.0],). Lead was associated with decreased PON1A (RR phenotype, T3 vs. T1 -18.9% [-32.5, -2.5]; T2 vs. T1 -19.6% [-32.4, -4.4]). Cadmium was associated with lower PON1P comparing T2 vs. T1 for the RR (-34.9% [-51.5, -12.5]) and QR phenotypes (-9.5% [-18.1, 0.0]) but not comparing T3 vs. T1. Cadmium was associated with increases in PON1P levels (QQ phenotype, T3 vs. T1 24.5% [7.0, 44.9]) and mercury was associated with increased PON1A levels (QQ phenotype, T3 vs. T1 6.2% [0.2, 12.6]). Mercury was associated with decreased PON1P (RR phenotype, T2 vs. T1 -22.8 [-37.8, -4.1]).<h4>Conclusion</h4>Blood metals were associated with PON1 activity and these effects varied by phenotype. However, there was not a linear dose-response and these findings await replication. |
| format | Article |
| id | doaj-art-86b6fceebd124f74b08202b84f24ca26 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-86b6fceebd124f74b08202b84f24ca262025-08-20T03:11:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9215210.1371/journal.pone.0092152Association of cadmium, lead and mercury with paraoxonase 1 activity in women.Anna Z PollackLindsey SjaardaKatherine A AhrensSunni L MumfordRichard W BrowneJean Wactawski-WendeEnrique F Schisterman<h4>Background</h4>The activity of paraoxonase 1 (PON1), an antioxidant enzyme whose polymorphisms have been associated with cancer risk, may be associated with metals exposure.<h4>Objective</h4>To evaluate PON1 activity in relation to cadmium, lead, and mercury levels in healthy, premenopausal women.<h4>Methods</h4>Women from upstate New York were followed for ≥ two menstrual cycles. Repeated measures linear mixed models estimated the association between cadmium, lead, and mercury levels (by tertile: T1, T2, T3) and PON1 arylesterase (PON1A) and PON1 paraoxonase (PON1P) activity, separately. Analyses were stratified by PON1 Q192R phenotype and un-stratified.<h4>Results</h4>Median blood cadmium, lead, and mercury concentrations were 0.30 µg/L, 0.87 µg/dL, and 1.15 µg/L. In un-stratified analyses cadmium and mercury were associated with decreased PON1A activity (T2 vs. T1; not T3 vs. T1) but metals were not associated with PON1P. Phenotypes were distributed between QQ (n = 99), QR (n = 117), and RR (n = 34). Cadmium was associated with decreased PON1A activity for QR and RR phenotypes comparing T2 vs. T1 (-14.4% 95% confidence interval [CI] [-20.1, -8.4] and -27.9% [-39.5, -14.0],). Lead was associated with decreased PON1A (RR phenotype, T3 vs. T1 -18.9% [-32.5, -2.5]; T2 vs. T1 -19.6% [-32.4, -4.4]). Cadmium was associated with lower PON1P comparing T2 vs. T1 for the RR (-34.9% [-51.5, -12.5]) and QR phenotypes (-9.5% [-18.1, 0.0]) but not comparing T3 vs. T1. Cadmium was associated with increases in PON1P levels (QQ phenotype, T3 vs. T1 24.5% [7.0, 44.9]) and mercury was associated with increased PON1A levels (QQ phenotype, T3 vs. T1 6.2% [0.2, 12.6]). Mercury was associated with decreased PON1P (RR phenotype, T2 vs. T1 -22.8 [-37.8, -4.1]).<h4>Conclusion</h4>Blood metals were associated with PON1 activity and these effects varied by phenotype. However, there was not a linear dose-response and these findings await replication.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092152&type=printable |
| spellingShingle | Anna Z Pollack Lindsey Sjaarda Katherine A Ahrens Sunni L Mumford Richard W Browne Jean Wactawski-Wende Enrique F Schisterman Association of cadmium, lead and mercury with paraoxonase 1 activity in women. PLoS ONE |
| title | Association of cadmium, lead and mercury with paraoxonase 1 activity in women. |
| title_full | Association of cadmium, lead and mercury with paraoxonase 1 activity in women. |
| title_fullStr | Association of cadmium, lead and mercury with paraoxonase 1 activity in women. |
| title_full_unstemmed | Association of cadmium, lead and mercury with paraoxonase 1 activity in women. |
| title_short | Association of cadmium, lead and mercury with paraoxonase 1 activity in women. |
| title_sort | association of cadmium lead and mercury with paraoxonase 1 activity in women |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092152&type=printable |
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