Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells
Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone, Haliotis discus hannai viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-i...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/526439 |
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| author | Ho-Seok Rho Hyang Kim Jung-Ae Kim Fatih Karadeniz Byul-Nim Ahn Ki-Ho Nam Youngwan Seo Chang-Suk Kong |
| author_facet | Ho-Seok Rho Hyang Kim Jung-Ae Kim Fatih Karadeniz Byul-Nim Ahn Ki-Ho Nam Youngwan Seo Chang-Suk Kong |
| author_sort | Ho-Seok Rho |
| collection | DOAJ |
| description | Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone, Haliotis discus hannai viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of H. discus hannai was evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence of H. discus hannai mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-α, IL-1β, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. Presence of AM also scavenged the free radicals in vitro. In conclusion, by-products of H. discus hannai are suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient. |
| format | Article |
| id | doaj-art-86a6ca6ba1bd458092488566e1b1a089 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-86a6ca6ba1bd458092488566e1b1a0892025-02-03T01:32:53ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/526439526439Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 CellsHo-Seok Rho0Hyang Kim1Jung-Ae Kim2Fatih Karadeniz3Byul-Nim Ahn4Ki-Ho Nam5Youngwan Seo6Chang-Suk Kong7Production Support Team, Marine Biotechnology Research Institute, Jeollanamdo 537-807, Republic of KoreaNutritional Education, Graduate School of Education, Silla University, Busan 617-736, Republic of KoreaDepartment of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, Republic of KoreaMarine Biotechnology Center for Pharmaceuticals and Foods, Silla University, Busan 617-736, Republic of KoreaDepartment of Organic Material Science and Engineering, Pusan National University, Busan 609-735, Republic of KoreaNational Fisheries Research & Development Institute, Food and Safety Research Center, Busan 619-705, Republic of KoreaDivision of Marine Environment and Bioscience, Korea Maritime University, Busan 606-791, Republic of KoreaDepartment of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, Republic of KoreaSeveral reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone, Haliotis discus hannai viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of H. discus hannai was evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence of H. discus hannai mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-α, IL-1β, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. Presence of AM also scavenged the free radicals in vitro. In conclusion, by-products of H. discus hannai are suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient.http://dx.doi.org/10.1155/2015/526439 |
| spellingShingle | Ho-Seok Rho Hyang Kim Jung-Ae Kim Fatih Karadeniz Byul-Nim Ahn Ki-Ho Nam Youngwan Seo Chang-Suk Kong Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells Journal of Chemistry |
| title | Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells |
| title_full | Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells |
| title_fullStr | Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells |
| title_full_unstemmed | Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells |
| title_short | Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells |
| title_sort | anti inflammatory effect of by products from haliotis discus hannai in raw 264 7 cells |
| url | http://dx.doi.org/10.1155/2015/526439 |
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