Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets
High carbohydrate (HC) diets have become a conventional approach in modern aquaculture. However, this feeding strategy frequently compromises the health of high-value economic fish species, which might ultimately impair the farmers’ final profits. Our prior research indicated that Saccharina japonic...
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Elsevier
2025-03-01
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| Series: | Aquaculture Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513424006264 |
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| author | Wenlu Zhu Huilin Zhang Haitao Pan Hao Zeng Wenjun Wang Yunfeng Liu Zirui Wang Qiubai Zhou Chuanqi Yu |
| author_facet | Wenlu Zhu Huilin Zhang Haitao Pan Hao Zeng Wenjun Wang Yunfeng Liu Zirui Wang Qiubai Zhou Chuanqi Yu |
| author_sort | Wenlu Zhu |
| collection | DOAJ |
| description | High carbohydrate (HC) diets have become a conventional approach in modern aquaculture. However, this feeding strategy frequently compromises the health of high-value economic fish species, which might ultimately impair the farmers’ final profits. Our prior research indicated that Saccharina japonica efficiently reduces harm from HC diets, likely due to its sodium alginate (SA) content. In this study, Monopterus albus were randomly grouped into treatments: a normal diet (20 % carbohydrate, NC), a high carbohydrate diet (32 % carbohydrate, HC), and high carbohydrate diets supplemented with 0.5 % SA (LA). Then our outcomes evinced that LA improves various health-related parameters, including reduction of hepatosomatic index (HSI), serum glucose, triglycerides, and aminotransferase levels, as well as the decrease in hepatic lipid droplets, glycogen, and collagen fiber content. Our transcriptomic analysis on liver tissue showed that detoxification-related differentially expressed genes (DEGs) were less active in HC group than in NC group. In contrast, DEGs linked to fatty acid synthesis increased in LA group versus HC group. A combined analysis of metagenomics and the short-chain fatty acids (SCFAs) profile in the posterior intestinal digesta indicated that LA diets greatly increased concentration of acetic acid. This effect was accompanied by a concurrent reduction in the abundance of the species Marinobacter guineae relative to HC diets. Overall, sodium alginate has demonstrated a substantial enhancement in Monopterus albus’ health by mitigating liver injury and ameliorating intestinal microbiota dysbiosis. |
| format | Article |
| id | doaj-art-86a5094ed8594f40a3c19fb6419540ce |
| institution | Kabale University |
| issn | 2352-5134 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj-art-86a5094ed8594f40a3c19fb6419540ce2025-02-06T05:12:03ZengElsevierAquaculture Reports2352-51342025-03-0140102538Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate dietsWenlu Zhu0Huilin Zhang1Haitao Pan2Hao Zeng3Wenjun Wang4Yunfeng Liu5Zirui Wang6Qiubai Zhou7Chuanqi Yu8Special Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, ChinaSpecial Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, ChinaSpecial Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, ChinaSpecial Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, ChinaSpecial Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, ChinaQingdao Luoan Biotechnology Co., Ltd, Qingdao 266000, ChinaSpecial Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, China; Corresponding authors at: Special fisheries research institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.Special Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, China; Corresponding authors at: Special fisheries research institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.Special Fisheries Research Institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China; Key Laboratory of Featured Hydrobios Nutritional Physiology and Healthy Breeding, Nanchang 330045, China; Corresponding authors at: Special fisheries research institute, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.High carbohydrate (HC) diets have become a conventional approach in modern aquaculture. However, this feeding strategy frequently compromises the health of high-value economic fish species, which might ultimately impair the farmers’ final profits. Our prior research indicated that Saccharina japonica efficiently reduces harm from HC diets, likely due to its sodium alginate (SA) content. In this study, Monopterus albus were randomly grouped into treatments: a normal diet (20 % carbohydrate, NC), a high carbohydrate diet (32 % carbohydrate, HC), and high carbohydrate diets supplemented with 0.5 % SA (LA). Then our outcomes evinced that LA improves various health-related parameters, including reduction of hepatosomatic index (HSI), serum glucose, triglycerides, and aminotransferase levels, as well as the decrease in hepatic lipid droplets, glycogen, and collagen fiber content. Our transcriptomic analysis on liver tissue showed that detoxification-related differentially expressed genes (DEGs) were less active in HC group than in NC group. In contrast, DEGs linked to fatty acid synthesis increased in LA group versus HC group. A combined analysis of metagenomics and the short-chain fatty acids (SCFAs) profile in the posterior intestinal digesta indicated that LA diets greatly increased concentration of acetic acid. This effect was accompanied by a concurrent reduction in the abundance of the species Marinobacter guineae relative to HC diets. Overall, sodium alginate has demonstrated a substantial enhancement in Monopterus albus’ health by mitigating liver injury and ameliorating intestinal microbiota dysbiosis.http://www.sciencedirect.com/science/article/pii/S2352513424006264Sodium alginateLiver injuryIntestinal microbiota dysbiosisHigh carbohydrate dietMultiple omics |
| spellingShingle | Wenlu Zhu Huilin Zhang Haitao Pan Hao Zeng Wenjun Wang Yunfeng Liu Zirui Wang Qiubai Zhou Chuanqi Yu Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets Aquaculture Reports Sodium alginate Liver injury Intestinal microbiota dysbiosis High carbohydrate diet Multiple omics |
| title | Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets |
| title_full | Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets |
| title_fullStr | Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets |
| title_full_unstemmed | Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets |
| title_short | Sodium alginate ameliorates health in freshwater fish through gut-liver axis modulation under high carbohydrate diets |
| title_sort | sodium alginate ameliorates health in freshwater fish through gut liver axis modulation under high carbohydrate diets |
| topic | Sodium alginate Liver injury Intestinal microbiota dysbiosis High carbohydrate diet Multiple omics |
| url | http://www.sciencedirect.com/science/article/pii/S2352513424006264 |
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