Chronic Q fever: An ongoing challenge in diagnosis and management
Chronic Q fever is a potentially fatal disease. The current difficulty in the diagnosis of this condition is discussed in the present article. A 51-year-old woman with a history of aortic valve replacement presented with complaints of feeling generally unwell, pyrexia and occasional unproductive cou...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2014/863678 |
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| _version_ | 1832561575844642816 |
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| author | Ira Das Nicola Guest Richard Steeds Peter Hewins |
| author_facet | Ira Das Nicola Guest Richard Steeds Peter Hewins |
| author_sort | Ira Das |
| collection | DOAJ |
| description | Chronic Q fever is a potentially fatal disease. The current difficulty in the diagnosis of this condition is discussed in the present article. A 51-year-old woman with a history of aortic valve replacement presented with complaints of feeling generally unwell, pyrexia and occasional unproductive cough over a period of several weeks. Phase 1 immunoglobulin G titre to Coxiella burnetii was initially detected at a low level (1:320, detected using immunofluorescence) and was not considered to be significant according to the modified Duke criteria. Later in the course of her illness, the patient’s antibody titre rose to a high level (1:1280). The issues regarding current laboratory diagnosis and management of Q fever are discussed. Chronic Q fever can be associated with an inadequate serological response. Close follow-up of cases is essential. The recommended serological criteria for the diagnosis of Q fever endocarditis needs to be revisited. |
| format | Article |
| id | doaj-art-86a23bb134a945758291f4f1ee4b61e1 |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-86a23bb134a945758291f4f1ee4b61e12025-02-03T01:24:39ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322014-01-01251353710.1155/2014/863678Chronic Q fever: An ongoing challenge in diagnosis and managementIra Das0Nicola Guest1Richard Steeds2Peter Hewins3Department of Clinical Microbiology & Infection Control, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United KingdomDepartment of Clinical Microbiology & Infection Control, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United KingdomDepartment of Cardiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United KingdomDepartment of Nephrology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United KingdomChronic Q fever is a potentially fatal disease. The current difficulty in the diagnosis of this condition is discussed in the present article. A 51-year-old woman with a history of aortic valve replacement presented with complaints of feeling generally unwell, pyrexia and occasional unproductive cough over a period of several weeks. Phase 1 immunoglobulin G titre to Coxiella burnetii was initially detected at a low level (1:320, detected using immunofluorescence) and was not considered to be significant according to the modified Duke criteria. Later in the course of her illness, the patient’s antibody titre rose to a high level (1:1280). The issues regarding current laboratory diagnosis and management of Q fever are discussed. Chronic Q fever can be associated with an inadequate serological response. Close follow-up of cases is essential. The recommended serological criteria for the diagnosis of Q fever endocarditis needs to be revisited.http://dx.doi.org/10.1155/2014/863678 |
| spellingShingle | Ira Das Nicola Guest Richard Steeds Peter Hewins Chronic Q fever: An ongoing challenge in diagnosis and management Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Chronic Q fever: An ongoing challenge in diagnosis and management |
| title_full | Chronic Q fever: An ongoing challenge in diagnosis and management |
| title_fullStr | Chronic Q fever: An ongoing challenge in diagnosis and management |
| title_full_unstemmed | Chronic Q fever: An ongoing challenge in diagnosis and management |
| title_short | Chronic Q fever: An ongoing challenge in diagnosis and management |
| title_sort | chronic q fever an ongoing challenge in diagnosis and management |
| url | http://dx.doi.org/10.1155/2014/863678 |
| work_keys_str_mv | AT iradas chronicqfeveranongoingchallengeindiagnosisandmanagement AT nicolaguest chronicqfeveranongoingchallengeindiagnosisandmanagement AT richardsteeds chronicqfeveranongoingchallengeindiagnosisandmanagement AT peterhewins chronicqfeveranongoingchallengeindiagnosisandmanagement |