Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis

Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis

Abstract Despite substantial advances in the antitumor effects of annonaceous acetogenins (ACGs), the absence of a defined biological action mechanism remains a major barrier to their clinical application. Here, it is found that squamocin effectively depletes both EZH2 and MYC in multiple cancer cel...

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Bibliographic Details
Main Authors: Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
annonaceous acetogenins
endoplasmic reticulum stress response
EZH2/MYC axis
squamocin
ubiquitin‐proteasome degradation system
Online Access:https://doi.org/10.1002/advs.202413120
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