Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters
Background/aims Lipid profiles have been changed in numerous chronic conditions. The impact of uveitis on lipid metabolism remains unclear.Methods This is a cross-sectional study included 416 patients with non-infectious uveitis (NIU) and 416 healthy subjects. Standard techniques were used to measur...
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BMJ Publishing Group
2024-05-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001641.full |
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| author | Lei Feng Guangming Qin Junhui Shen |
| author_facet | Lei Feng Guangming Qin Junhui Shen |
| author_sort | Lei Feng |
| collection | DOAJ |
| description | Background/aims Lipid profiles have been changed in numerous chronic conditions. The impact of uveitis on lipid metabolism remains unclear.Methods This is a cross-sectional study included 416 patients with non-infectious uveitis (NIU) and 416 healthy subjects. Standard techniques were used to measure total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDLc), low-density lipoprotein-cholesterol (LDLc) levels. Quantitative optical coherence tomography angiography (OCTA) parameters were obtained from 500 eyes in each group. Correlation analysis examined the relationship between lipid profile and OCTA parameters.Results Patients with NIU exhibited significantly elevated TC, TG and LDLc levels compared with controls (p=0.003; p<0.001; p<0.001, respectively). Subgroup analysis revealed that HDLc was significantly lower in Behçet’s disease (p=0.024) compared with controls. Vascular density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris and optic disk were significantly decreased in NIU eyes (p<0.05, respectively) compared with controls. HDLc exhibited a significant negative correlation with VDs in the whole and parafovea SCP (r=−0.489, p=0.008; r=−0.480, p=0.0026, respectively), while LDLc showed a significant positive correlation with VDs in the whole and parafovea DCP in NIU patients (r=0.576, p=0.032; r=0.267, p=0.034, respectively).Conclusions The lipid profile is altered in NIU, and there are correlations between HDLc and LDLc levels and VD as measured by OCTA. Lipid profile analysis may offer valuable insights into evaluating vascular and metabolic aspects of NIU. |
| format | Article |
| id | doaj-art-869f060f52284d4d9ddeccbded4d782a |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open Ophthalmology |
| spelling | doaj-art-869f060f52284d4d9ddeccbded4d782a2025-02-06T14:10:09ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-05-019110.1136/bmjophth-2024-001641Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parametersLei Feng0Guangming Qin1Junhui Shen21 Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeEye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaEye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBackground/aims Lipid profiles have been changed in numerous chronic conditions. The impact of uveitis on lipid metabolism remains unclear.Methods This is a cross-sectional study included 416 patients with non-infectious uveitis (NIU) and 416 healthy subjects. Standard techniques were used to measure total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDLc), low-density lipoprotein-cholesterol (LDLc) levels. Quantitative optical coherence tomography angiography (OCTA) parameters were obtained from 500 eyes in each group. Correlation analysis examined the relationship between lipid profile and OCTA parameters.Results Patients with NIU exhibited significantly elevated TC, TG and LDLc levels compared with controls (p=0.003; p<0.001; p<0.001, respectively). Subgroup analysis revealed that HDLc was significantly lower in Behçet’s disease (p=0.024) compared with controls. Vascular density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris and optic disk were significantly decreased in NIU eyes (p<0.05, respectively) compared with controls. HDLc exhibited a significant negative correlation with VDs in the whole and parafovea SCP (r=−0.489, p=0.008; r=−0.480, p=0.0026, respectively), while LDLc showed a significant positive correlation with VDs in the whole and parafovea DCP in NIU patients (r=0.576, p=0.032; r=0.267, p=0.034, respectively).Conclusions The lipid profile is altered in NIU, and there are correlations between HDLc and LDLc levels and VD as measured by OCTA. Lipid profile analysis may offer valuable insights into evaluating vascular and metabolic aspects of NIU.https://bmjophth.bmj.com/content/9/1/e001641.full |
| spellingShingle | Lei Feng Guangming Qin Junhui Shen Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters BMJ Open Ophthalmology |
| title | Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters |
| title_full | Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters |
| title_fullStr | Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters |
| title_full_unstemmed | Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters |
| title_short | Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters |
| title_sort | lipid profile alterations in non infectious uveitis correlation with quantitative optical coherence tomography angiography parameters |
| url | https://bmjophth.bmj.com/content/9/1/e001641.full |
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