Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation
Interleukin-18 (IL-18), a proinflammatory cytokine, is produced by oral epithelia and carcinoma cells and implicated in tumor regression. Since its direct biological effect on oral cancer cells is not well defined, in this study, we employed a KB cell line to test IL-18 activity. Recombinant human I...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/67120 |
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| _version_ | 1832561923957194752 |
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| author | Athip Nilkaeo Suthinee Bhuvanath |
| author_facet | Athip Nilkaeo Suthinee Bhuvanath |
| author_sort | Athip Nilkaeo |
| collection | DOAJ |
| description | Interleukin-18 (IL-18), a proinflammatory cytokine, is produced by oral epithelia and carcinoma cells and implicated in tumor regression. Since its direct biological effect on oral cancer cells is not well defined, in this study, we employed a KB cell line to test IL-18 activity. Recombinant human IL-18 significantly inhibited KB cell proliferation in a dose-dependent fashion (P<.05) without increasing cytotoxicity. Analysis of its mode of action showed that IL-18 induced cell cycle arrest in the S phase; however, it did not trigger apoptotic cell death. Findings in this study indicate that the suppression of KB cell proliferation was attributed to the modulation of cell cycle progression, providing a new role of this cytokine in antitumor mechanisms. |
| format | Article |
| id | doaj-art-869d6c2fe8ff4a68975e9f57f4693637 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-869d6c2fe8ff4a68975e9f57f46936372025-02-03T01:23:48ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/6712067120Role of Interleukin-18 in Modulation of Oral Carcinoma Cell ProliferationAthip Nilkaeo0Suthinee Bhuvanath1Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla 90112, ThailandDepartment of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla 90112, ThailandInterleukin-18 (IL-18), a proinflammatory cytokine, is produced by oral epithelia and carcinoma cells and implicated in tumor regression. Since its direct biological effect on oral cancer cells is not well defined, in this study, we employed a KB cell line to test IL-18 activity. Recombinant human IL-18 significantly inhibited KB cell proliferation in a dose-dependent fashion (P<.05) without increasing cytotoxicity. Analysis of its mode of action showed that IL-18 induced cell cycle arrest in the S phase; however, it did not trigger apoptotic cell death. Findings in this study indicate that the suppression of KB cell proliferation was attributed to the modulation of cell cycle progression, providing a new role of this cytokine in antitumor mechanisms.http://dx.doi.org/10.1155/MI/2006/67120 |
| spellingShingle | Athip Nilkaeo Suthinee Bhuvanath Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation Mediators of Inflammation |
| title | Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation |
| title_full | Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation |
| title_fullStr | Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation |
| title_full_unstemmed | Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation |
| title_short | Role of Interleukin-18 in Modulation of Oral Carcinoma Cell Proliferation |
| title_sort | role of interleukin 18 in modulation of oral carcinoma cell proliferation |
| url | http://dx.doi.org/10.1155/MI/2006/67120 |
| work_keys_str_mv | AT athipnilkaeo roleofinterleukin18inmodulationoforalcarcinomacellproliferation AT suthineebhuvanath roleofinterleukin18inmodulationoforalcarcinomacellproliferation |