Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors
Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinic...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/8642989 |
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| _version_ | 1832548898532491264 |
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| author | Jeong-Kee Yoon Mi-Lan Kang Joo Hyun Park Kyoung-Mi Lee Young Min Shin Jin Woo Lee Hyun Ok Kim Hak-Joon Sung |
| author_facet | Jeong-Kee Yoon Mi-Lan Kang Joo Hyun Park Kyoung-Mi Lee Young Min Shin Jin Woo Lee Hyun Ok Kim Hak-Joon Sung |
| author_sort | Jeong-Kee Yoon |
| collection | DOAJ |
| description | Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinical performance. Since native microenvironment factors including stem cell niche, genetic factors, and growth factors direct stem cell fate cooperatively, user-specified in vitro settings are required to understand the regulatory roles and effects of each factor, thereby applying the factors for improved cell therapy. Among others, various types of biomaterials and transfection method have been employed as key tools for development of the in vitro settings. This review focuses on the current strategies to improve stemness maintenance, direct differentiation, and reprogramming using biomaterials and genetic factors without any aids from additional biochemicals and growth factors. |
| format | Article |
| id | doaj-art-868529ab5bb340bc870a5c078fff26b9 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-868529ab5bb340bc870a5c078fff26b92025-02-03T06:12:44ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/86429898642989Direct Control of Stem Cell Behavior Using Biomaterials and Genetic FactorsJeong-Kee Yoon0Mi-Lan Kang1Joo Hyun Park2Kyoung-Mi Lee3Young Min Shin4Jin Woo Lee5Hyun Ok Kim6Hak-Joon Sung7Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Republic of KoreaSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Republic of KoreaSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Republic of KoreaSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Republic of KoreaDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Republic of KoreaStem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinical performance. Since native microenvironment factors including stem cell niche, genetic factors, and growth factors direct stem cell fate cooperatively, user-specified in vitro settings are required to understand the regulatory roles and effects of each factor, thereby applying the factors for improved cell therapy. Among others, various types of biomaterials and transfection method have been employed as key tools for development of the in vitro settings. This review focuses on the current strategies to improve stemness maintenance, direct differentiation, and reprogramming using biomaterials and genetic factors without any aids from additional biochemicals and growth factors.http://dx.doi.org/10.1155/2018/8642989 |
| spellingShingle | Jeong-Kee Yoon Mi-Lan Kang Joo Hyun Park Kyoung-Mi Lee Young Min Shin Jin Woo Lee Hyun Ok Kim Hak-Joon Sung Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors Stem Cells International |
| title | Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors |
| title_full | Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors |
| title_fullStr | Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors |
| title_full_unstemmed | Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors |
| title_short | Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors |
| title_sort | direct control of stem cell behavior using biomaterials and genetic factors |
| url | http://dx.doi.org/10.1155/2018/8642989 |
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