TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research

Given that angiogenesis and lymphangiogenesis are strongly related to prognosis in neoplastic and other pathologies and that many methods exist that provide different results, we aim to construct a morphometric tool allowing us to measure different aspects of the shape and size of vascular vessels i...

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Main Authors: M. Milagro Fernández-Carrobles, Irene Tadeo, Gloria Bueno, Rosa Noguera, Oscar Déniz, Jesús Salido, Marcial García-Rojo
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2013/263190
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author M. Milagro Fernández-Carrobles
Irene Tadeo
Gloria Bueno
Rosa Noguera
Oscar Déniz
Jesús Salido
Marcial García-Rojo
author_facet M. Milagro Fernández-Carrobles
Irene Tadeo
Gloria Bueno
Rosa Noguera
Oscar Déniz
Jesús Salido
Marcial García-Rojo
author_sort M. Milagro Fernández-Carrobles
collection DOAJ
description Given that angiogenesis and lymphangiogenesis are strongly related to prognosis in neoplastic and other pathologies and that many methods exist that provide different results, we aim to construct a morphometric tool allowing us to measure different aspects of the shape and size of vascular vessels in a complete and accurate way. The developed tool presented is based on vessel closing which is an essential property to properly characterize the size and the shape of vascular and lymphatic vessels. The method is fast and accurate improving existing tools for angiogenesis analysis. The tool also improves the accuracy of vascular density measurements, since the set of endothelial cells forming a vessel is considered as a single object.
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id doaj-art-868148da0fbc4edb801447e00638646d
institution Kabale University
issn 1537-744X
language English
publishDate 2013-01-01
publisher Wiley
record_format Article
series The Scientific World Journal
spelling doaj-art-868148da0fbc4edb801447e00638646d2025-02-03T01:20:42ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/263190263190TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis ResearchM. Milagro Fernández-Carrobles0Irene Tadeo1Gloria Bueno2Rosa Noguera3Oscar Déniz4Jesús Salido5Marcial García-Rojo6VISILAB, E.T.S.I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real, SpainFundación Investigación Clínico de Valencia, Instituto de Investigación Sanitaria, INCLIVA, 46010 Valencia, SpainVISILAB, E.T.S.I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real, SpainLaboratorio de Patología Molecular, Departmento de Patología, Facultad de Medicina y Odontología, Universidad de Valencia, 46010 Valencia, SpainVISILAB, E.T.S.I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real, SpainVISILAB, E.T.S.I. Industriales, Universidad de Castilla-La Mancha, 13071 Ciudad Real, SpainDepartmento de Anatomía Patológica, Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, SpainGiven that angiogenesis and lymphangiogenesis are strongly related to prognosis in neoplastic and other pathologies and that many methods exist that provide different results, we aim to construct a morphometric tool allowing us to measure different aspects of the shape and size of vascular vessels in a complete and accurate way. The developed tool presented is based on vessel closing which is an essential property to properly characterize the size and the shape of vascular and lymphatic vessels. The method is fast and accurate improving existing tools for angiogenesis analysis. The tool also improves the accuracy of vascular density measurements, since the set of endothelial cells forming a vessel is considered as a single object.http://dx.doi.org/10.1155/2013/263190
spellingShingle M. Milagro Fernández-Carrobles
Irene Tadeo
Gloria Bueno
Rosa Noguera
Oscar Déniz
Jesús Salido
Marcial García-Rojo
TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research
The Scientific World Journal
title TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research
title_full TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research
title_fullStr TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research
title_full_unstemmed TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research
title_short TMA Vessel Segmentation Based on Color and Morphological Features: Application to Angiogenesis Research
title_sort tma vessel segmentation based on color and morphological features application to angiogenesis research
url http://dx.doi.org/10.1155/2013/263190
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