Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy
Objectives: To assess disability and quality of life (QOL) in treatment resistant schizophrenia (TRS) on long term clozapine therapy and assess their correlation with positive, negative and cognitive symptoms. Methodology: Disability and QOL in forty patients with TRS (as per modified Kane’s criteri...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-06-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_320_22 |
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| author | Dhandapani Nandakumar Ragul Ganesh Koushik S. Deb Raka Jain Mamta Sood |
| author_facet | Dhandapani Nandakumar Ragul Ganesh Koushik S. Deb Raka Jain Mamta Sood |
| author_sort | Dhandapani Nandakumar |
| collection | DOAJ |
| description | Objectives:
To assess disability and quality of life (QOL) in treatment resistant schizophrenia (TRS) on long term clozapine therapy and assess their correlation with positive, negative and cognitive symptoms.
Methodology:
Disability and QOL in forty patients with TRS (as per modified Kane’s criteria) were assessed using World Health Organization Disability Assessment Schedule 2.0 and World Health Organization Quality of Life–BREF. Scale for assessment of positive symptoms, scale for assessment of negative symptoms and Addenbrooke’s cognitive examination-III were used to assess positive, negative and cognitive symptoms. Medication adherence rating scale assessed medication adherence.
Results:
Disability and QOL correlated significantly with medication adherence, negative and cognitive symptoms but not with positive symptoms. Subgroup analysis revealed significant difference between medication adherence (good vs poor) and cognitive (impairment vs non-impairment) groups.
Conclusion:
Negative and cognitive symptoms, and medication adherence correlated with disability and QOL. |
| format | Article |
| id | doaj-art-866d75a47d6143e88e7e9392811d2b72 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-866d75a47d6143e88e7e9392811d2b722025-01-22T14:56:56ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-06-0165669469710.4103/indianjpsychiatry.indianjpsychiatry_320_22Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapyDhandapani NandakumarRagul GaneshKoushik S. DebRaka JainMamta SoodObjectives: To assess disability and quality of life (QOL) in treatment resistant schizophrenia (TRS) on long term clozapine therapy and assess their correlation with positive, negative and cognitive symptoms. Methodology: Disability and QOL in forty patients with TRS (as per modified Kane’s criteria) were assessed using World Health Organization Disability Assessment Schedule 2.0 and World Health Organization Quality of Life–BREF. Scale for assessment of positive symptoms, scale for assessment of negative symptoms and Addenbrooke’s cognitive examination-III were used to assess positive, negative and cognitive symptoms. Medication adherence rating scale assessed medication adherence. Results: Disability and QOL correlated significantly with medication adherence, negative and cognitive symptoms but not with positive symptoms. Subgroup analysis revealed significant difference between medication adherence (good vs poor) and cognitive (impairment vs non-impairment) groups. Conclusion: Negative and cognitive symptoms, and medication adherence correlated with disability and QOL.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_320_22clozapinedisabilityquality of lifetreatment-resistant schizophrenia |
| spellingShingle | Dhandapani Nandakumar Ragul Ganesh Koushik S. Deb Raka Jain Mamta Sood Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy Indian Journal of Psychiatry clozapine disability quality of life treatment-resistant schizophrenia |
| title | Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy |
| title_full | Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy |
| title_fullStr | Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy |
| title_full_unstemmed | Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy |
| title_short | Disability and quality of life in patients with treatment-resistant schizophrenia on long- term clozapine therapy |
| title_sort | disability and quality of life in patients with treatment resistant schizophrenia on long term clozapine therapy |
| topic | clozapine disability quality of life treatment-resistant schizophrenia |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_320_22 |
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