Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex
Previous work by us and others has shown that the loss of interaction between GATA4 and FOG2 protein partners is embryonic lethal due to heart failure at embryonic day (E) 13.5; however, the role of this important protein duo in various cardiac compartments (e.g., myocardial, endocardial, or epicard...
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| Language: | English |
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Wiley
2009-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2009.75 |
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| author | Nikolay L. Manuylov Sergei G. Tevosian |
| author_facet | Nikolay L. Manuylov Sergei G. Tevosian |
| author_sort | Nikolay L. Manuylov |
| collection | DOAJ |
| description | Previous work by us and others has shown that the loss of interaction between GATA4 and FOG2 protein partners is embryonic lethal due to heart failure at embryonic day (E) 13.5; however, the role of this important protein duo in various cardiac compartments (e.g., myocardial, endocardial, or epicardial cells) remains to be understood. Although a dual role (both as an activator and a repressor) for the GATA4-FOG2 transcriptional complex has been put forward, the specific genes under GATA4-FOG2 control in the developing heart have remained largely elusive. Since the myocardial-restricted Fog2 re-expression in the Fog2 null embryos is sufficient to extend their life span, identification of GATA4-FOG2 target genes in cardiomyocytes could shed light on the molecular mechanism of GATA4-FOG2 action in these cells. We report here that cardiac expression of slow skeletal troponin T (Tnnt1) strictly depends on the physical interaction between GATA4-FOG2 in the myocardium of both atria and ventricles. |
| format | Article |
| id | doaj-art-866b84faffdf48b8a05a4f2093e97bd0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-866b84faffdf48b8a05a4f2093e97bd02025-02-03T07:24:32ZengWileyThe Scientific World Journal1537-744X2009-01-01957558710.1100/tsw.2009.75Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription ComplexNikolay L. Manuylov0Sergei G. Tevosian1Department of Genetics, Dartmouth Medical School, Hanover, NH, USADepartment of Genetics, Dartmouth Medical School, Hanover, NH, USAPrevious work by us and others has shown that the loss of interaction between GATA4 and FOG2 protein partners is embryonic lethal due to heart failure at embryonic day (E) 13.5; however, the role of this important protein duo in various cardiac compartments (e.g., myocardial, endocardial, or epicardial cells) remains to be understood. Although a dual role (both as an activator and a repressor) for the GATA4-FOG2 transcriptional complex has been put forward, the specific genes under GATA4-FOG2 control in the developing heart have remained largely elusive. Since the myocardial-restricted Fog2 re-expression in the Fog2 null embryos is sufficient to extend their life span, identification of GATA4-FOG2 target genes in cardiomyocytes could shed light on the molecular mechanism of GATA4-FOG2 action in these cells. We report here that cardiac expression of slow skeletal troponin T (Tnnt1) strictly depends on the physical interaction between GATA4-FOG2 in the myocardium of both atria and ventricles.http://dx.doi.org/10.1100/tsw.2009.75 |
| spellingShingle | Nikolay L. Manuylov Sergei G. Tevosian Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex The Scientific World Journal |
| title | Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex |
| title_full | Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex |
| title_fullStr | Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex |
| title_full_unstemmed | Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex |
| title_short | Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex |
| title_sort | cardiac expression of tnnt1 requires the gata4 fog2 transcription complex |
| url | http://dx.doi.org/10.1100/tsw.2009.75 |
| work_keys_str_mv | AT nikolaylmanuylov cardiacexpressionoftnnt1requiresthegata4fog2transcriptioncomplex AT sergeigtevosian cardiacexpressionoftnnt1requiresthegata4fog2transcriptioncomplex |