Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy
Epilepsy as a common neurological disease is mostly managed effectively with antiepileptic medications. One-third of patients do not respond to medical treatments requiring alternative therapies. Vagus nerve stimulation (VNS) has been used in the last decades for the treatment of medically resistant...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2021/9927311 |
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| author | Mehdi Abbasi Atie Moghtadaie Seyed Amir Miratashi Yazdi |
| author_facet | Mehdi Abbasi Atie Moghtadaie Seyed Amir Miratashi Yazdi |
| author_sort | Mehdi Abbasi |
| collection | DOAJ |
| description | Epilepsy as a common neurological disease is mostly managed effectively with antiepileptic medications. One-third of patients do not respond to medical treatments requiring alternative therapies. Vagus nerve stimulation (VNS) has been used in the last decades for the treatment of medically resistant epilepsy. Despite the extensive use of VNS in these patients, factors associated with clinical outcomes of VNS remain to be elucidated. In this study, we evaluated factors affecting VNS outcomes in epileptic patients to have a better understanding of patients who are better candidates for VNS therapy. Several databases including PubMed, Scopus, and Google Scholar were searched through June 2020 for relevant articles. The following factors were assessed in this review: previous surgical history, age at implantation and gender, types of epilepsy, duration of epilepsy, age at epilepsy onset, frequency of attacks, antiepileptic drugs, VNS parameters, EEG findings, MRI findings, and biomarkers. Literature data show that nonresponder rates range between 25% and 65%. Given the complexity and diversity of factors associated with response to VNS, more clinical studies are needed to establish better paradigm for selection of patients for VNS therapy. |
| format | Article |
| id | doaj-art-866a4ec225d246849d0d39f245c77459 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-866a4ec225d246849d0d39f245c774592025-02-03T01:00:48ZengWileyNeurology Research International2090-18522090-18602021-01-01202110.1155/2021/99273119927311Factors Affecting Vagus Nerve Stimulation Outcomes in EpilepsyMehdi Abbasi0Atie Moghtadaie1Seyed Amir Miratashi Yazdi2Radiology Department, Mayo Clinic, Rochester, MN, USAInternal Medicine Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, IranGeneral Surgery Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, IranEpilepsy as a common neurological disease is mostly managed effectively with antiepileptic medications. One-third of patients do not respond to medical treatments requiring alternative therapies. Vagus nerve stimulation (VNS) has been used in the last decades for the treatment of medically resistant epilepsy. Despite the extensive use of VNS in these patients, factors associated with clinical outcomes of VNS remain to be elucidated. In this study, we evaluated factors affecting VNS outcomes in epileptic patients to have a better understanding of patients who are better candidates for VNS therapy. Several databases including PubMed, Scopus, and Google Scholar were searched through June 2020 for relevant articles. The following factors were assessed in this review: previous surgical history, age at implantation and gender, types of epilepsy, duration of epilepsy, age at epilepsy onset, frequency of attacks, antiepileptic drugs, VNS parameters, EEG findings, MRI findings, and biomarkers. Literature data show that nonresponder rates range between 25% and 65%. Given the complexity and diversity of factors associated with response to VNS, more clinical studies are needed to establish better paradigm for selection of patients for VNS therapy.http://dx.doi.org/10.1155/2021/9927311 |
| spellingShingle | Mehdi Abbasi Atie Moghtadaie Seyed Amir Miratashi Yazdi Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy Neurology Research International |
| title | Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy |
| title_full | Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy |
| title_fullStr | Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy |
| title_full_unstemmed | Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy |
| title_short | Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy |
| title_sort | factors affecting vagus nerve stimulation outcomes in epilepsy |
| url | http://dx.doi.org/10.1155/2021/9927311 |
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