Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage
IntroductionThe electric signals within the cartilage tissue are essential to biological systems and play a significant role in cartilage regeneration. Therefore, this study analyzed and investigated the reverse mechano-electrical effect in porcine articular cartilage and its related influencing fac...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1485593/full |
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| author | Chunsheng Liu Le Zhao Hao Dong Zekun Hua Yanqin Wang Yongxing Wang Pengcui Li Xiaochun Wei Kai Zhang Yanru Xue Xiaogang Wu Weiyi Chen |
| author_facet | Chunsheng Liu Le Zhao Hao Dong Zekun Hua Yanqin Wang Yongxing Wang Pengcui Li Xiaochun Wei Kai Zhang Yanru Xue Xiaogang Wu Weiyi Chen |
| author_sort | Chunsheng Liu |
| collection | DOAJ |
| description | IntroductionThe electric signals within the cartilage tissue are essential to biological systems and play a significant role in cartilage regeneration. Therefore, this study analyzed and investigated the reverse mechano-electrical effect in porcine articular cartilage and its related influencing factors.MethodsThe deflection of cartilage samples in an electric field was measured to analyze the mechanisms of different factors affecting the reverse mechano-electrical effect in articular cartilage.ResultsThe results showed that the cartilage thickness, water content, and externally applied voltage all impacted the deflection of the cartilage. The reduction in cartilage water content resulted in a decrease in cartilage thickness, following the same influencing mechanism as thickness. On the other hand, an increase in the externally applied voltage led to an increase in the electric field force within the cartilage space, consequently increasing the deflection of the cartilage in the electric field. Additionally, the externally applied voltage also caused a slight temperature rise in the vicinity of the cartilage specimens, and the magnitude of the temperature increase was proportional to the externally applied voltage.DiscussionThe fitting results of the experimental data indicated that cartilage thickness influenced the dielectric constant and moment of inertia of the cartilage in the electric field, thereby affecting the magnitude of the electric field force and deflection of the cartilage. This may provide valuable insights for further investigation into the microscopic mechanisms of cell proliferation, differentiation, and cartilage regeneration induced by electrical stimulation. |
| format | Article |
| id | doaj-art-865c48890c564f85a4f9fbc049a21858 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-865c48890c564f85a4f9fbc049a218582025-02-03T06:33:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.14855931485593Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilageChunsheng Liu0Le Zhao1Hao Dong2Zekun Hua3Yanqin Wang4Yongxing Wang5Pengcui Li6Xiaochun Wei7Kai Zhang8Yanru Xue9Xiaogang Wu10Weiyi Chen11College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaTaiyuan Great Health Technology Health Management Co., Ltd., Taiyuan, ChinaShanxi Provincial Key Laboratory for Repair of Bone and Soft Tissue Injury, Taiyuan, ChinaShanxi Provincial Key Laboratory for Repair of Bone and Soft Tissue Injury, Taiyuan, ChinaHuajin Orthopaedic Hospital, Taiyuan, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, ChinaIntroductionThe electric signals within the cartilage tissue are essential to biological systems and play a significant role in cartilage regeneration. Therefore, this study analyzed and investigated the reverse mechano-electrical effect in porcine articular cartilage and its related influencing factors.MethodsThe deflection of cartilage samples in an electric field was measured to analyze the mechanisms of different factors affecting the reverse mechano-electrical effect in articular cartilage.ResultsThe results showed that the cartilage thickness, water content, and externally applied voltage all impacted the deflection of the cartilage. The reduction in cartilage water content resulted in a decrease in cartilage thickness, following the same influencing mechanism as thickness. On the other hand, an increase in the externally applied voltage led to an increase in the electric field force within the cartilage space, consequently increasing the deflection of the cartilage in the electric field. Additionally, the externally applied voltage also caused a slight temperature rise in the vicinity of the cartilage specimens, and the magnitude of the temperature increase was proportional to the externally applied voltage.DiscussionThe fitting results of the experimental data indicated that cartilage thickness influenced the dielectric constant and moment of inertia of the cartilage in the electric field, thereby affecting the magnitude of the electric field force and deflection of the cartilage. This may provide valuable insights for further investigation into the microscopic mechanisms of cell proliferation, differentiation, and cartilage regeneration induced by electrical stimulation.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1485593/fullarticular cartilagereverse mechano-electrical effectcartilage’s thicknessdeflectionexternal electric field |
| spellingShingle | Chunsheng Liu Le Zhao Hao Dong Zekun Hua Yanqin Wang Yongxing Wang Pengcui Li Xiaochun Wei Kai Zhang Yanru Xue Xiaogang Wu Weiyi Chen Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage Frontiers in Bioengineering and Biotechnology articular cartilage reverse mechano-electrical effect cartilage’s thickness deflection external electric field |
| title | Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage |
| title_full | Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage |
| title_fullStr | Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage |
| title_full_unstemmed | Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage |
| title_short | Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage |
| title_sort | experimental investigation on the reverse mechano electrical effect of porcine articular cartilage |
| topic | articular cartilage reverse mechano-electrical effect cartilage’s thickness deflection external electric field |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1485593/full |
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