Quality assessment of furosemide tablet generics used in a teaching hospital in Nigeria
The use of ineffective and poor-quality drugs endangers treatment leading to treatment failure. For the desired therapeutic effect, drugs should contain the appropriate amount of active pharmaceutical ingredients and the required physicochemical properties. This study aimed to evaluate the quality...
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| Format: | Article |
| Language: | English |
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University of Nigeria
2025-02-01
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| Series: | African Journal of Pharmaceutical Research and Development (AJOPRED) |
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| Online Access: | https://www.ajol.info/index.php/ajopred/article/view/288095 |
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| author | Abdurrahman Umar Halimatu Sadiya Hassan Salisu Awwalu |
| author_facet | Abdurrahman Umar Halimatu Sadiya Hassan Salisu Awwalu |
| author_sort | Abdurrahman Umar |
| collection | DOAJ |
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The use of ineffective and poor-quality drugs endangers treatment leading to treatment failure. For the desired therapeutic effect, drugs should contain the appropriate amount of active pharmaceutical ingredients and the required physicochemical properties. This study aimed to evaluate the quality as well as the physicochemical properties of different generics of furosemide tablets used in a teaching hospital in Nigeria. Five different generics of furosemide tablets were purchased from different pharmacy units in the hospital. Their qualities were assessed via identification, assay, weight variation, friability, disintegration and dissolution tests using British Pharmacopoeia standards. All samples contain the stated active pharmaceutical ingredients, however, only two generics have furosemide within the 95 – 105% BP official limit. The weight variation test results indicated that two generics failed to comply with BP specification limits. The generics were found to be able to withstand the rigour of transportation as indicated by their friability values of less than 1 %. The generics were also found to be immediate release tablets as showed by their rapid disintegration time of less than 2 minutes. All the generics released more than 80 % furosemide within 60 minutes. Only two out of the five furosemide generics passed the quality assessment and are therefore expected to yield the desired therapeutic effect.
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| format | Article |
| id | doaj-art-865b67515f474637b46b9653e590ef15 |
| institution | Kabale University |
| issn | 0794-800X 1596-2431 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | University of Nigeria |
| record_format | Article |
| series | African Journal of Pharmaceutical Research and Development (AJOPRED) |
| spelling | doaj-art-865b67515f474637b46b9653e590ef152025-02-02T19:50:48ZengUniversity of NigeriaAfrican Journal of Pharmaceutical Research and Development (AJOPRED)0794-800X1596-24312025-02-01163Quality assessment of furosemide tablet generics used in a teaching hospital in NigeriaAbdurrahman Umar0Halimatu Sadiya HassanSalisu AwwaluDepartment of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University Zaria, Nigeria. The use of ineffective and poor-quality drugs endangers treatment leading to treatment failure. For the desired therapeutic effect, drugs should contain the appropriate amount of active pharmaceutical ingredients and the required physicochemical properties. This study aimed to evaluate the quality as well as the physicochemical properties of different generics of furosemide tablets used in a teaching hospital in Nigeria. Five different generics of furosemide tablets were purchased from different pharmacy units in the hospital. Their qualities were assessed via identification, assay, weight variation, friability, disintegration and dissolution tests using British Pharmacopoeia standards. All samples contain the stated active pharmaceutical ingredients, however, only two generics have furosemide within the 95 – 105% BP official limit. The weight variation test results indicated that two generics failed to comply with BP specification limits. The generics were found to be able to withstand the rigour of transportation as indicated by their friability values of less than 1 %. The generics were also found to be immediate release tablets as showed by their rapid disintegration time of less than 2 minutes. All the generics released more than 80 % furosemide within 60 minutes. Only two out of the five furosemide generics passed the quality assessment and are therefore expected to yield the desired therapeutic effect. https://www.ajol.info/index.php/ajopred/article/view/288095Quality assessmentWeight variationAssay, DisintegrationDissolutionFurosemide tablets |
| spellingShingle | Abdurrahman Umar Halimatu Sadiya Hassan Salisu Awwalu Quality assessment of furosemide tablet generics used in a teaching hospital in Nigeria African Journal of Pharmaceutical Research and Development (AJOPRED) Quality assessment Weight variation Assay, Disintegration Dissolution Furosemide tablets |
| title | Quality assessment of furosemide tablet generics used in a teaching hospital in Nigeria |
| title_full | Quality assessment of furosemide tablet generics used in a teaching hospital in Nigeria |
| title_fullStr | Quality assessment of furosemide tablet generics used in a teaching hospital in Nigeria |
| title_full_unstemmed | Quality assessment of furosemide tablet generics used in a teaching hospital in Nigeria |
| title_short | Quality assessment of furosemide tablet generics used in a teaching hospital in Nigeria |
| title_sort | quality assessment of furosemide tablet generics used in a teaching hospital in nigeria |
| topic | Quality assessment Weight variation Assay, Disintegration Dissolution Furosemide tablets |
| url | https://www.ajol.info/index.php/ajopred/article/view/288095 |
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