Acute Diacetylmorphine (Heroin) Intoxication (Review)
This review presents current data on the mechanism of action, selective toxicity, toxicokinetics and toxicodynamics of diacetylmorphine (heroin). Acute diacetylmorphine poisoning is considered under taking into account the developing a critical state, in which the poisoning severity is determined by...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2017-01-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1563 |
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| author | A. T. Loladze G. A. Livanov B. V. Batotsyrenov A. L. Kovalenko A. N. Lodyagin S. I. Glushkov D. V. Baranov A. M. Antonova T. V. Kharitonova |
| author_facet | A. T. Loladze G. A. Livanov B. V. Batotsyrenov A. L. Kovalenko A. N. Lodyagin S. I. Glushkov D. V. Baranov A. M. Antonova T. V. Kharitonova |
| author_sort | A. T. Loladze |
| collection | DOAJ |
| description | This review presents current data on the mechanism of action, selective toxicity, toxicokinetics and toxicodynamics of diacetylmorphine (heroin). Acute diacetylmorphine poisoning is considered under taking into account the developing a critical state, in which the poisoning severity is determined by severe metabolic disorders associated with the progression of hypoxia. The main lifethreatening complications of acute diacetyl morphine poisoning are described including those associated with the nervous system, respiratory, circulatory and urinary systems. Since hypoxia is the principal damaging factor, the the mechanisms of oxygen transport disorders and the pathogenesis of activation of free radical oxidation in acute diacetylmorphine poisoning are discussed. The improvement of intensive care strategy for severe forms of acute diacetylmorphine poisoning by the inclusion of a substrate antihypoxant Reamberin into the list of routine critical care prescriptions is emphesized. |
| format | Article |
| id | doaj-art-86596c702bda47dfb04c679689206f4e |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-86596c702bda47dfb04c679689206f4e2025-08-20T02:59:34ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102017-01-01126648110.15360/1813-9779-2016-6-64-811537Acute Diacetylmorphine (Heroin) Intoxication (Review)A. T. Loladze0G. A. Livanov1B. V. Batotsyrenov2A. L. Kovalenko3A. N. Lodyagin4S. I. Glushkov5D. V. Baranov6A. M. Antonova7T. V. Kharitonova8I. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineInstitute of Toxicology, Federal Medico-Biological Agency of RussiaI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency Medicine I. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineI. I. Dzhanelidze Saint-Petersburg Research Institute of Emergency MedicineThis review presents current data on the mechanism of action, selective toxicity, toxicokinetics and toxicodynamics of diacetylmorphine (heroin). Acute diacetylmorphine poisoning is considered under taking into account the developing a critical state, in which the poisoning severity is determined by severe metabolic disorders associated with the progression of hypoxia. The main lifethreatening complications of acute diacetyl morphine poisoning are described including those associated with the nervous system, respiratory, circulatory and urinary systems. Since hypoxia is the principal damaging factor, the the mechanisms of oxygen transport disorders and the pathogenesis of activation of free radical oxidation in acute diacetylmorphine poisoning are discussed. The improvement of intensive care strategy for severe forms of acute diacetylmorphine poisoning by the inclusion of a substrate antihypoxant Reamberin into the list of routine critical care prescriptions is emphesized.https://www.reanimatology.com/rmt/article/view/1563acute poisoningdiacetylmorphineheroinhypoxianaloxonesubstrate antihypoxantsreamberin |
| spellingShingle | A. T. Loladze G. A. Livanov B. V. Batotsyrenov A. L. Kovalenko A. N. Lodyagin S. I. Glushkov D. V. Baranov A. M. Antonova T. V. Kharitonova Acute Diacetylmorphine (Heroin) Intoxication (Review) Общая реаниматология acute poisoning diacetylmorphine heroin hypoxia naloxone substrate antihypoxants reamberin |
| title | Acute Diacetylmorphine (Heroin) Intoxication (Review) |
| title_full | Acute Diacetylmorphine (Heroin) Intoxication (Review) |
| title_fullStr | Acute Diacetylmorphine (Heroin) Intoxication (Review) |
| title_full_unstemmed | Acute Diacetylmorphine (Heroin) Intoxication (Review) |
| title_short | Acute Diacetylmorphine (Heroin) Intoxication (Review) |
| title_sort | acute diacetylmorphine heroin intoxication review |
| topic | acute poisoning diacetylmorphine heroin hypoxia naloxone substrate antihypoxants reamberin |
| url | https://www.reanimatology.com/rmt/article/view/1563 |
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