Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort
Objective Risk prediction models are used to determine eligibility for targeted lung cancer screening. However, prospective data regarding model performance in this setting are limited. Here we report the performance of the PLCOm2012 risk model, which calculates 6 year lung cancer risk, in a cohort...
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| Format: | Article |
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BMJ Publishing Group
2024-07-01
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| Series: | BMJ Oncology |
| Online Access: | https://bmjoncology.bmj.com/content/3/1/e000560.full |
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| author | Matthew Sperrin Haval Balata Richard Booton Hilary A Robbins Philip A J Crosbie Patrick Goodley |
| author_facet | Matthew Sperrin Haval Balata Richard Booton Hilary A Robbins Philip A J Crosbie Patrick Goodley |
| author_sort | Matthew Sperrin |
| collection | DOAJ |
| description | Objective Risk prediction models are used to determine eligibility for targeted lung cancer screening. However, prospective data regarding model performance in this setting are limited. Here we report the performance of the PLCOm2012 risk model, which calculates 6 year lung cancer risk, in a cohort invited for lung cancer screening in a socioeconomically deprived area.Methods and analysis Calibration (expected/observed (E/O) lung cancer diagnoses over 6 years) and discrimination (area under the receiver operating characteristic curve) of PLCOm2012 and other models was performed in Manchester Lung Health Check (M-LHC) participants, where PLCOm2012 ≥1.51% was used prospectively to determine screening eligibility. Lung cancers diagnosed by any route were captured within 6 years of risk assessment, for both screened and non-screened participants. Performance of a range of models was evaluated.Results Out of 2541 attendees, 56% were high-risk (n=1430/2541) and offered screening; 44% were low-risk (n=1111/2541) and not screened. Over 6 years, 7.3% (n=105/1430) and 0.9% (n=10/1111) were diagnosed with lung cancer in the high and low-risk cohorts, respectively (p<0.0001). Risk was underestimated in both high-risk, screened (E/O 0.68 (0.57–0.82)) and low-risk, unscreened groups (E/O 0.61 (0.33–1.14)). Most other models also underestimated risk.Conclusion Risk-based eligibility using PLCOm2012 successfully classified most eventual lung cancer cases in the high-risk, screened group. Prediction models generally underestimated risk in this socioeconomically deprived cohort, irrespective of screening status. The effect of screening on increasing the probability of lung cancer diagnosis should be considered when interpreting measures of prediction model performance. |
| format | Article |
| id | doaj-art-864497fd9b0540b2815f6a83785ca965 |
| institution | Kabale University |
| issn | 2752-7948 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Oncology |
| spelling | doaj-art-864497fd9b0540b2815f6a83785ca9652025-01-30T08:40:12ZengBMJ Publishing GroupBMJ Oncology2752-79482024-07-013110.1136/bmjonc-2024-000560Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohortMatthew Sperrin0Haval Balata1Richard Booton2Hilary A Robbins3Philip A J Crosbie4Patrick Goodley5Division of Informatics, Imaging and Data Science, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UKDivision of Immunology, Immunity to Infection and Respiratory Medicine, The University of Manchester, Manchester, UKDivision of Immunology, Immunity to Infection and Respiratory Medicine, The University of Manchester, Manchester, UKInternational Agency for Research on Cancer, Lyon, FranceDivision of Immunology, Immunity to Infection and Respiratory Medicine, The University of Manchester, Manchester, UKDivision of Immunology, Immunity to Infection and Respiratory Medicine, The University of Manchester, Manchester, UKObjective Risk prediction models are used to determine eligibility for targeted lung cancer screening. However, prospective data regarding model performance in this setting are limited. Here we report the performance of the PLCOm2012 risk model, which calculates 6 year lung cancer risk, in a cohort invited for lung cancer screening in a socioeconomically deprived area.Methods and analysis Calibration (expected/observed (E/O) lung cancer diagnoses over 6 years) and discrimination (area under the receiver operating characteristic curve) of PLCOm2012 and other models was performed in Manchester Lung Health Check (M-LHC) participants, where PLCOm2012 ≥1.51% was used prospectively to determine screening eligibility. Lung cancers diagnosed by any route were captured within 6 years of risk assessment, for both screened and non-screened participants. Performance of a range of models was evaluated.Results Out of 2541 attendees, 56% were high-risk (n=1430/2541) and offered screening; 44% were low-risk (n=1111/2541) and not screened. Over 6 years, 7.3% (n=105/1430) and 0.9% (n=10/1111) were diagnosed with lung cancer in the high and low-risk cohorts, respectively (p<0.0001). Risk was underestimated in both high-risk, screened (E/O 0.68 (0.57–0.82)) and low-risk, unscreened groups (E/O 0.61 (0.33–1.14)). Most other models also underestimated risk.Conclusion Risk-based eligibility using PLCOm2012 successfully classified most eventual lung cancer cases in the high-risk, screened group. Prediction models generally underestimated risk in this socioeconomically deprived cohort, irrespective of screening status. The effect of screening on increasing the probability of lung cancer diagnosis should be considered when interpreting measures of prediction model performance.https://bmjoncology.bmj.com/content/3/1/e000560.full |
| spellingShingle | Matthew Sperrin Haval Balata Richard Booton Hilary A Robbins Philip A J Crosbie Patrick Goodley Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort BMJ Oncology |
| title | Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort |
| title_full | Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort |
| title_fullStr | Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort |
| title_full_unstemmed | Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort |
| title_short | Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort |
| title_sort | six year performance of risk based selection for lung cancer screening in the manchester lung health check cohort |
| url | https://bmjoncology.bmj.com/content/3/1/e000560.full |
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