Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches

Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches

Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing conditions characterized by dysregulated immune responses and persistent intestinal inflammation. This review aims to examine new potential therapeutic targets in IBD starting from the...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lucia Centanni, Clelia Cicerone, Fabrizio Fanizzi, Ferdinando D’Amico, Federica Furfaro, Alessandra Zilli, Tommaso Lorenzo Parigi, Laurent Peyrin-Biroulet, Silvio Danese, Mariangela Allocca
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Pharmaceuticals
Subjects:	new therapeutic targets clinical remission endoscopic remission histologic remission transmural remission deep remission
Online Access:	https://www.mdpi.com/1424-8247/18/1/78
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus
by: Mehmet Enes Güner, et al.
Published: (2025-01-01)

Rate and predictors of response to glucocorticoid therapy in patients of takayasu arteritis at a tertiary level hospital of Bangladesh: A longitudinal study
by: Farzana Shumy, et al.
Published: (2021-01-01)

Exploration of rituximab treatment strategies for membranous nephropathy adapted to the Chinese healthcare environment
by: Xiaolong Wang, et al.
Published: (2025-01-01)

Changes in clinical and imaging variables during withdrawal of heart failure therapy in recovered dilated cardiomyopathy
by: Brian P. Halliday, et al.
Published: (2022-06-01)

Application of morphological criteria for definition of management approach for child with ulcerative colitis
by: E. N. Fedulova, et al.
Published: (2012-07-01)

Development of machine learning models for predicting non-remission in early RA highlights the robust predictive importance of the RAID score-evidence from the ARCTIC study
by: Gaoyang Li, et al.
Published: (2025-02-01)

Association Between Patient-Reported Pain and Remission or Low Disease Activity in Patients with Rheumatoid Arthritis: Data from RA-BE-REAL Prospective Observational Study
by: Peter C. Taylor, et al.
Published: (2024-12-01)

Changes in Serum Immunoglobulin Levels Play as Predictors of Treatment Response and Prognosis in Pediatric Idiopathic Nephrotic Syndrome During the Remission Phase
by: Amin sadat Sharif, et al.
Published: (2025-01-01)

The use of oral topically acting glucocorticosteroids in the treatment of inflammatory bowel disease
by: P. Rutgeerts
Published: (1998-01-01)

Comparing International Guidelines for the Remission of Hypertension After Bariatric Surgery
by: Carina Vieira Dias, et al.
Published: (2025-01-01)

Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
by: Aysegul Oruc, et al.
Published: (2024-12-01)

Management and outcomes among older adults with generalized epilepsy in routine clinical practice
by: MarieElena Byrnes, et al.
Published: (2025-02-01)

Immunological Remission as a Basis for Dose Reduction of Immunosuppressors in Autoimmune Hepatitis: Results of Monocenter Surveillance Study
by: A. O. Bueverov, et al.
Published: (2024-03-01)

Efficacy and safety of avacopan in antineutrophil cytoplasmic autoantibody-associated vasculitis: a retrospective cohort study in Japan
by: Genri Tagami, et al.
Published: (2025-01-01)

A retrospective cohort study of biosimilar rituximab therapy in pemphigus: experience from a tertiary care hospital in North India
by: Sabha Mushtaq, et al.
Published: (2024-11-01)

A class of constrained optimal control problems arising in an immunotherapy cancer remission process
by: Yineng Ouyang, et al.
Published: (2024-10-01)

Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and healthy controls
by: Yidan Wang, et al.
Published: (2025-01-01)

The effect of rehabilitation on remission following detoxification treatment in alcohol and substance use disorders: A pilot study
by: Mustafa Danisman, et al.
Published: (2024-04-01)

C-Reactive Protein As A Response Indicator In Drug-Naïve Patients With Major Depressive Disorder: A Hospital-Based Study
by: Ather Muneer, et al.
Published: (2023-12-01)

Impact of diabetes remission or progression on the incidence of cardiovascular disease in Japan: historical cohort study using a nationwide claims database
by: Chihiro Shimayama, et al.
Published: (2025-01-01)

The Uncoupling of Disease Activity from Joint Structural Progression in Patients with Rheumatoid Arthritis Treated with Filgotinib
by: Yoshiya Tanaka, et al.
Published: (2024-11-01)

A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder
by: Didakamiwan Khonglah, et al.
Published: (2023-04-01)

Efficacy of short term non steroidal anti-inflammatory drugs in Indian patients with axial spondyloarthritis
by: Shubha Bhalla, et al.
Published: (2018-01-01)

Frequency of remission achievement in the pre-treat-to-target decade in juvenile idiopathic arthritis
by: Ana Isabel Rebollo-Giménez, et al.
Published: (2025-01-01)

Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review
by: Ming Cheng, et al.
Published: (2025-02-01)

Remission: does it already exist in chronic rhinosinusitis with nasal polyposis?
by: Yvonne Chan, et al.
Published: (2023-07-01)

The oral disposition index calculated from a meal tolerance test is a crucial indicator for evaluating differential normalization of postprandial glucose and triglyceride excursions in morbidly obese patients after laparoscopic sleeve gastrectomy
by: Yukako Yamamoto, et al.
Published: (2023-12-01)

Association between previous consumption of sugar-sweetened beverages and diabetes remission in patients with newly diagnosed type 2 diabetic ketoacidosis
by: Shanshan Li, et al.
Published: (2024-09-01)

Long-term effects of dupilumab on chronic rhinosinusitis with nasal polyps: A step towards clinical remission
by: Mona Al-Ahmad, MD, FRCPC, et al.
Published: (2025-02-01)

Type 2 diabetes remission through lifestyle intervention in a geriatric patient with long-standing diabetes and at thirty-three-months follow-up
by: Pramod Tripathi, et al.
Published: (2025-02-01)

Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report
by: Yihong Ran, et al.
Published: (2025-01-01)

Outcomes Following Metabolic Bariatric Surgery at a Single Center in the United Arab Emirates
by: Allum M, et al.
Published: (2025-01-01)

A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves’ disease: a real-world study
by: Xide Chen, et al.
Published: (2025-01-01)

Les lettres de rémission des ducs de Bourgogne. Étude sur les normativités sociales, politiques et juridiques
by: Rudi Beaulant
Published: (2020-01-01)

Prognostic value of circulatory growth factors to predict responsiveness to chemotherapy and remission status of patients with acute myeloid leukemia
by: Mohammad Ahmad Bani-Ahmad, et al.
Published: (2024-05-01)

Immunotherapy as a neoadjuvant preoperative treatment for locally advanced pulmonary sarcomatoid carcinoma: a case report of clinical efficacy
by: Hanhan Li, et al.
Published: (2025-01-01)

Real-World Persistence and Effectiveness of Upadacitinib versus Other Janus Kinase Inhibitors and Tumor Necrosis Factor Inhibitors in Australian Patients with Rheumatoid Arthritis
by: Peter Youssef, et al.
Published: (2025-01-01)

Role of Probiotics in the Management of Patients with Ulcerative Colitis and Pouchitis
by: Francesca Bernardi, et al.
Published: (2024-12-01)

Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study
by: Manami Nomura, et al.
Published: (2025-02-01)

Analysis of different therapeutic schemes combining cyclophosphamide and doublestranded DNA preparation for eradication of Krebs-2 primary ascites in mice
by: E. A. Potter, et al.
Published: (2016-03-01)