The effective-compound compatibility of JHF inhibits fibroblast activation in pulmonary fibrosis by enhancing PINK1/PARK2-mediated mitophagy

The effective-compound compatibility of JHF inhibits fibroblast activation in pulmonary fibrosis by enhancing PINK1/PARK2-mediated mitophagy

Abstract This work aimed to elucidate the anti-PF mechanism of ECC-JHF.The effects of ECC-JHF on lung fibrosis and fibroblast activation were investigated by establishing a BLM-induced PF rat model and a transforming growth factor-beta (TGF-β)-induced fibroblast activation model. Furthermore, the ef...

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Bibliographic Details
Main Authors: Yunping Bai, Xiaohong Yin, Qin Zhang, Xingjie Sang, Wenjing Wu, Dong Shao, Peng Zhao, Jiansheng Li
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Pulmonary fibrosis
Effective-compound combination
Fibroblasts activation
Nrf2
Mitophagy
Online Access:https://doi.org/10.1038/s41598-025-95175-8
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