Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length
Background: Telomere length(TL)and mitochondrial DNA copy number(mtDNAcn) are classic biomarker of aging. Recently, growth differentiation factor 15(GDF15) has attracted considerable attention as a vital component in the aging process. Methods: The present study aimed to study the relationship betwe...
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Elsevier
2025-04-01
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| Series: | The Journal of Nutrition, Health and Aging |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1279770725000168 |
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| author | Jie Yu Yiwen Liu Huabing Zhang Fan Ping Wei Li Lingling Xu Yuxiu Li |
| author_facet | Jie Yu Yiwen Liu Huabing Zhang Fan Ping Wei Li Lingling Xu Yuxiu Li |
| author_sort | Jie Yu |
| collection | DOAJ |
| description | Background: Telomere length(TL)and mitochondrial DNA copy number(mtDNAcn) are classic biomarker of aging. Recently, growth differentiation factor 15(GDF15) has attracted considerable attention as a vital component in the aging process. Methods: The present study aimed to study the relationship between GDF15 and telomere length and mtDNAcn.This was a cross-sectional analysis nested in a longitudinal cohort study conducted in Changping District, Beijing, from 2014 to 2021. Serum GDF15,leukocyte lelomere length(LTL) and mtDNAcn were determined in 802 subjects.LTL and mtDNAcn was quantified by real-time PCR assay. Multivariate linear regression and restricted cubic spline diagram were used for statistical analysis. Results: Subjects with higher GDF15 were older,had larger waist circumference, higher systolic blood pressure and glycated hemoglobin A1c (HbA1c),shorter LTL and tended to had less mtDNAcn. In correlation analysis, GDF15 was positively correlated with age, while LTL and mtDNAcn were negatively correlated with age.After adjusting for confounding factors,GDF15 was negatively associated with LTL (β = −0.120, 95%CI [−0.197, −0.042], p = 0.003) and the association was linear(p for nonlinear = 0.645), while the negative association between GDF15 and mtDNAcn did not reach significance.In the stratified analyses,the negative associations between GDF15 and LTL were more prominent in women, overweight individuals, or subjects with abnormal glucose tolerance (AGT), but similar results were observed in younger and older subjects. Conclusions: This study found a linear negative association between GDF 15 and LTL,which was more prominent in women, overweight or AGT subjects.These results supported that GDF15 might be a reliable biomarker of aging. |
| format | Article |
| id | doaj-art-8633c177f1cf4a88bf96967b6af60572 |
| institution | Kabale University |
| issn | 1760-4788 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Nutrition, Health and Aging |
| spelling | doaj-art-8633c177f1cf4a88bf96967b6af605722025-02-04T04:10:19ZengElsevierThe Journal of Nutrition, Health and Aging1760-47882025-04-01294100493Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere LengthJie Yu0Yiwen Liu1Huabing Zhang2Fan Ping3Wei Li4Lingling Xu5Yuxiu Li6Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730Corresponding author.; Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730Corresponding author.; Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730Background: Telomere length(TL)and mitochondrial DNA copy number(mtDNAcn) are classic biomarker of aging. Recently, growth differentiation factor 15(GDF15) has attracted considerable attention as a vital component in the aging process. Methods: The present study aimed to study the relationship between GDF15 and telomere length and mtDNAcn.This was a cross-sectional analysis nested in a longitudinal cohort study conducted in Changping District, Beijing, from 2014 to 2021. Serum GDF15,leukocyte lelomere length(LTL) and mtDNAcn were determined in 802 subjects.LTL and mtDNAcn was quantified by real-time PCR assay. Multivariate linear regression and restricted cubic spline diagram were used for statistical analysis. Results: Subjects with higher GDF15 were older,had larger waist circumference, higher systolic blood pressure and glycated hemoglobin A1c (HbA1c),shorter LTL and tended to had less mtDNAcn. In correlation analysis, GDF15 was positively correlated with age, while LTL and mtDNAcn were negatively correlated with age.After adjusting for confounding factors,GDF15 was negatively associated with LTL (β = −0.120, 95%CI [−0.197, −0.042], p = 0.003) and the association was linear(p for nonlinear = 0.645), while the negative association between GDF15 and mtDNAcn did not reach significance.In the stratified analyses,the negative associations between GDF15 and LTL were more prominent in women, overweight individuals, or subjects with abnormal glucose tolerance (AGT), but similar results were observed in younger and older subjects. Conclusions: This study found a linear negative association between GDF 15 and LTL,which was more prominent in women, overweight or AGT subjects.These results supported that GDF15 might be a reliable biomarker of aging.http://www.sciencedirect.com/science/article/pii/S1279770725000168Growth differentiation factor 15Leukocyte telomere lengthMitochondrial DNA copy numberAging |
| spellingShingle | Jie Yu Yiwen Liu Huabing Zhang Fan Ping Wei Li Lingling Xu Yuxiu Li Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length The Journal of Nutrition, Health and Aging Growth differentiation factor 15 Leukocyte telomere length Mitochondrial DNA copy number Aging |
| title | Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length |
| title_full | Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length |
| title_fullStr | Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length |
| title_full_unstemmed | Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length |
| title_short | Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length |
| title_sort | serum growth differentiation factor 15 is negatively associated with leukocyte telomere length |
| topic | Growth differentiation factor 15 Leukocyte telomere length Mitochondrial DNA copy number Aging |
| url | http://www.sciencedirect.com/science/article/pii/S1279770725000168 |
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