Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s Thyroiditis
The aim of the present prospective study was to evaluate the predictive value of elastography in benign thyroid nodules of patients affected by Hashimoto’s thyroiditis (HT). From January 2011 to January 2012, 242 nodules in patients affected by HT were submitted to fine needle aspiration cytology (F...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/367054 |
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| author | Carlo Cappelli Ilenia Pirola Elena Gandossi Annamaria Formenti Barbara Agosti Maurizio Castellano |
| author_facet | Carlo Cappelli Ilenia Pirola Elena Gandossi Annamaria Formenti Barbara Agosti Maurizio Castellano |
| author_sort | Carlo Cappelli |
| collection | DOAJ |
| description | The aim of the present prospective study was to evaluate the predictive value of elastography in benign thyroid nodules of patients affected by Hashimoto’s thyroiditis (HT). From January 2011 to January 2012, 242 nodules in patients affected by HT were submitted to fine needle aspiration cytology (FNAC). All of the patients underwent sonography and elastography performed before FNAC. 230 (95%) nodules were benign, 8 papillary cancers, and 4 follicular lesions. Score 1 was found in 79.1% of benign lesions (sensitivity 79.1%; specificity 66.7%; PPV 97.8%; NPV 14.3%; accuracy 78.5%; p<0.05). In order to evaluate the outcome of thyroid ultrasound echogenicity in relation to elastography features of nodule(s), all the patients with benign nodules were stratified according to their hypoechoic pattern of thyroid (mild-moderate and severe). Following stratification score 1 was found in 84.2% of benign nodules (sensitivity 75.0%; specificity 88.9%; PPV 27.3%; NPV 98.4%; accuracy 88.2%; p<0.0001) of patients with a mild-moderate ultrasound thyroid hypoechogenicity, whereas it was found in 60% of benign nodules (p=0.715) of patients with a marked thyroid hypoechogenicity. Elastography appears to have limited value in detecting thyroid cancer in patients affected by Hashimoto’s thyroiditis with severe hypoechoic thyroid tissue. |
| format | Article |
| id | doaj-art-863323c5a92d4d4c9014db2791038bcf |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-863323c5a92d4d4c9014db2791038bcf2025-02-03T01:12:58ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/367054367054Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s ThyroiditisCarlo Cappelli0Ilenia Pirola1Elena Gandossi2Annamaria Formenti3Barbara Agosti4Maurizio Castellano5Department of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Piazzale Spedali Civili No. 1, 25100 Brescia, ItalyDepartment of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Piazzale Spedali Civili No. 1, 25100 Brescia, ItalyDepartment of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Piazzale Spedali Civili No. 1, 25100 Brescia, ItalyDepartment of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Piazzale Spedali Civili No. 1, 25100 Brescia, ItalyDepartment of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Piazzale Spedali Civili No. 1, 25100 Brescia, ItalyDepartment of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Piazzale Spedali Civili No. 1, 25100 Brescia, ItalyThe aim of the present prospective study was to evaluate the predictive value of elastography in benign thyroid nodules of patients affected by Hashimoto’s thyroiditis (HT). From January 2011 to January 2012, 242 nodules in patients affected by HT were submitted to fine needle aspiration cytology (FNAC). All of the patients underwent sonography and elastography performed before FNAC. 230 (95%) nodules were benign, 8 papillary cancers, and 4 follicular lesions. Score 1 was found in 79.1% of benign lesions (sensitivity 79.1%; specificity 66.7%; PPV 97.8%; NPV 14.3%; accuracy 78.5%; p<0.05). In order to evaluate the outcome of thyroid ultrasound echogenicity in relation to elastography features of nodule(s), all the patients with benign nodules were stratified according to their hypoechoic pattern of thyroid (mild-moderate and severe). Following stratification score 1 was found in 84.2% of benign nodules (sensitivity 75.0%; specificity 88.9%; PPV 27.3%; NPV 98.4%; accuracy 88.2%; p<0.0001) of patients with a mild-moderate ultrasound thyroid hypoechogenicity, whereas it was found in 60% of benign nodules (p=0.715) of patients with a marked thyroid hypoechogenicity. Elastography appears to have limited value in detecting thyroid cancer in patients affected by Hashimoto’s thyroiditis with severe hypoechoic thyroid tissue.http://dx.doi.org/10.1155/2015/367054 |
| spellingShingle | Carlo Cappelli Ilenia Pirola Elena Gandossi Annamaria Formenti Barbara Agosti Maurizio Castellano Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s Thyroiditis International Journal of Endocrinology |
| title | Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s Thyroiditis |
| title_full | Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s Thyroiditis |
| title_fullStr | Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s Thyroiditis |
| title_full_unstemmed | Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s Thyroiditis |
| title_short | Elastography Evaluation of Benign Thyroid Nodules in Patients Affected by Hashimoto’s Thyroiditis |
| title_sort | elastography evaluation of benign thyroid nodules in patients affected by hashimoto s thyroiditis |
| url | http://dx.doi.org/10.1155/2015/367054 |
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