Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment
Cell death mechanisms are broadly classified into accidental cell death (ACD) and regulated cell death (RCD). ACD such as necrosis, is an uncontrolled, accidental process, while RCD is tightly regulated by specific signaling pathways and molecular mechanisms. Tumor cells are characterized by their a...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1519119/full |
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| author | Yizheng Zhang Shiqi Yi Mingyuan Luan |
| author_facet | Yizheng Zhang Shiqi Yi Mingyuan Luan |
| author_sort | Yizheng Zhang |
| collection | DOAJ |
| description | Cell death mechanisms are broadly classified into accidental cell death (ACD) and regulated cell death (RCD). ACD such as necrosis, is an uncontrolled, accidental process, while RCD is tightly regulated by specific signaling pathways and molecular mechanisms. Tumor cells are characterized by their ability to evade cell death and sustain uncontrolled proliferation. The failure of programmed cell death is a key contributor to tumor initiation, progression, and resistance to cancer therapies. Traditionally, research has focused primarily on apoptosis as the dominant form of RCD in cancer. However, emerging evidence highlights the importance of other non-apoptotic forms of RCD, such as pyroptosis, ferroptosis, necroptosis, and parthanatos, in tumorigenesis and treatment response. These pathways are gaining attention for their potential roles in overcoming therapy resistance. In this review, we will discuss the recent advances in the study of non-apoptotic cell death pathways in malignant tumors and explore their therapeutic implications, offering insights into new targets for cancer treatment strategies. |
| format | Article |
| id | doaj-art-86322e21d3f64cc3b917d98b2fedbc09 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-86322e21d3f64cc3b917d98b2fedbc092025-01-30T05:10:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15191191519119Advances in non-apoptotic regulated cell death: implications for malignant tumor treatmentYizheng Zhang0Shiqi Yi1Mingyuan Luan2Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, GermanyDepartment of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, ChinaDepartment of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen, GermanyCell death mechanisms are broadly classified into accidental cell death (ACD) and regulated cell death (RCD). ACD such as necrosis, is an uncontrolled, accidental process, while RCD is tightly regulated by specific signaling pathways and molecular mechanisms. Tumor cells are characterized by their ability to evade cell death and sustain uncontrolled proliferation. The failure of programmed cell death is a key contributor to tumor initiation, progression, and resistance to cancer therapies. Traditionally, research has focused primarily on apoptosis as the dominant form of RCD in cancer. However, emerging evidence highlights the importance of other non-apoptotic forms of RCD, such as pyroptosis, ferroptosis, necroptosis, and parthanatos, in tumorigenesis and treatment response. These pathways are gaining attention for their potential roles in overcoming therapy resistance. In this review, we will discuss the recent advances in the study of non-apoptotic cell death pathways in malignant tumors and explore their therapeutic implications, offering insights into new targets for cancer treatment strategies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1519119/fullregulated cell deathtumorigenesiscancer treatmentpyroptosisnecroptosisferroptosis |
| spellingShingle | Yizheng Zhang Shiqi Yi Mingyuan Luan Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment Frontiers in Oncology regulated cell death tumorigenesis cancer treatment pyroptosis necroptosis ferroptosis |
| title | Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment |
| title_full | Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment |
| title_fullStr | Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment |
| title_full_unstemmed | Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment |
| title_short | Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment |
| title_sort | advances in non apoptotic regulated cell death implications for malignant tumor treatment |
| topic | regulated cell death tumorigenesis cancer treatment pyroptosis necroptosis ferroptosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1519119/full |
| work_keys_str_mv | AT yizhengzhang advancesinnonapoptoticregulatedcelldeathimplicationsformalignanttumortreatment AT shiqiyi advancesinnonapoptoticregulatedcelldeathimplicationsformalignanttumortreatment AT mingyuanluan advancesinnonapoptoticregulatedcelldeathimplicationsformalignanttumortreatment |